113795-29-2Relevant academic research and scientific papers
Synthesis and Hypolipidemic Activity of 2-Substituted Isobutyric Acid Derivatives
Morishita, Shin-ichi,Saito, Takashi,Hirai, Yasuharu,Shoji, Masamichi,Mishima, Yasuhiro,Kawakami, Masato
, p. 1205 - 1209 (2007/10/02)
A series of 2-substituted isobutyric acid derivatives have been synthesized and evaluated as hypolipidemic agents.Compounds 11 and 20 were found to decrease the level of plasma total cholesterol in experimental hyperlipidemic rats to a greater extent than clofibrate (CF) and to increase the level of plasma high-density lipoprotein cholesterol to the same extent as gemfibrozil (GF).Increase in liver weight caused by these compounds were less than those with CF and GF.
