34591-21-4

Upstream product

• 2657-25-2 4'-hydroxychalcone 
• 21148-30-1 3-(4-hydroxyphenyl)-1-phenylprop-1-ene 
• 20426-12-4 (E)-3-(4-hydroxyphenyl)-1-phenyl-2-propen-1-one 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 
• 38239-55-3 4-hydroxychalcone 
• 98-86-2 acetophenone 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 61078-39-5 1-Benzyloxy-4-((1S,2R)-2-phenyl-cyclopropyl)-benzene 
• 126582-25-0 1,1-dichloro-cis-2-(4-benzyloxyphenyl)-3-phenylcyclopropane 

Downstream Products

• 170012-73-4 1-acetoxy-4-(3-phenyl-propyl)-benzene 
• 61270-17-5 1-[2-hydroxy-5-(3-phenyl-propyl)-phenyl]-ethanone 
• 113795-29-2 1-(3-Bromo-propoxy)-4-(3-phenyl-propyl)-benzene 
• 113795-05-4 2,2-Dimethyl-5-[4-(3-phenyl-propyl)-phenoxy]-pentanoic acid 

Relevant academic research and scientific papers

Thermolysis of Surface-Attached 1,3-Diphenylpropane: Radical Chain Induced Decomposition under Conditions of Restricted Diffusion

Surface-immobilized 1,3-diphenylpropane (Ph(CH2)3Ph, or DPP) has been prepared by the condensation of p-(3-phenylpropyl)phenol with the surface hydroxyl groups of an amorphous, fumed silica.Thermolysis studies of the covalently attached DPP have

Synthesis and Bioactivity of Reduced Chalcones Containing Sulfonamide Side Chains

The effect on the bioactivity of antibacterial sulfonamide drugs against malaria and tuberculosis via an increase of the lipid solubility groups by condensation with a reduced chalcone was investigated. Sulfonamide derivatives (8a-8d) were obtained via a

Syntheses and in Vitro Antiplasmodial Activity of Aminoalkylated Chalcones and Analogues

(Chemical Equqation Presented). A series of readily synthesized and inexpensive aminoalkylated chalcones and diarylpropane analogues (1-55) were synthesized and tested against chloroquinone-sensitive (D10 and NF54) and -resistant (Dd2 and K1) strains of Plasmodium falciparum. Hydrogenation of the enone to a diarylpropane moiety increased antiplasmodial bioactivity significantly. The influence of the structure of the amine moiety, A-ring substituents, propyl vs ethyl linker, and chloride salt formation on further enhancing antiplasmodial activity was investigated. Several compounds have IC50 values similar to or better than chloroquine (CQ). The most active compound (26) had an IC50 value of 0.01 μM. No signs of resistance were detected, as can be expected from compounds with structures unrelated to CQ and other currently used antimalarial drugs. Toxicity tests (in vitro CHO cell assay) gave high SI indices.

SYNTHESIS OF ATR AND LIGHT SENSITIVE CIS-PHENOLIC CYCLOPROPANE DERIVATIVES

The synthesis of several cis-phenolic cyclopropanes, 6, 7, 8 and 13 is described.These cyclopropanes are new potential antiestrogens.A hydrogenolysis study of precursors, 5b, 5c, 5d, 10, 11, and 12, and a novel method for the prevention of gem-dichlorocyclopropane ring-opening during hydrogenolysis are discussed.