1138-44-9

Basic information

• Product Name: 2-phenethylcyclohexan-1-one
• Synonyms: 2-phenethylcyclohexan-1-one
• CAS NO: 1138-44-9
• Molecular Formula: C₁₄H₁₈O
• Molecular Weight: 0
• Mol File: 1138-44-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 320.1°Cat760mmHg
• Flash Point: 135.5°C
• Appearance: /
• Density: 1.005g/cm³
• Vapor Pressure: 0.000324mmHg at 25°C
• Refractive Index: 1.524
• CAS DataBase Reference: 2-phenethylcyclohexan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenethylcyclohexan-1-one(1138-44-9)
• EPA Substance Registry System: 2-phenethylcyclohexan-1-one(1138-44-9)

Safety Data

• Hazardous Substances Data: 1138-44-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H18O/c15-14-9-5-4-8-13(14)11-10-12-6-2-1-3-7-12/h1-3,6-7,13H,4-5,8-11H2

Upstream product

• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 
• 103-63-9 1-phenyl-2-bromoethane 
• 100-42-5 styrene 
• 108-94-1 cyclohexanone 
• 37810-16-5 N-cyclohexylidene-2-methylpropan-2-amine 
• 622-24-2 2-phenylethyl chloride 
• 75428-95-4 potassium 1-(ethoxycarbonyl)-2-oxocyclohexan-1-ide 
• 41302-34-5 2-(methoxycarbonyl)cyclohexanone 
• 2562-37-0 1-nitrocyclohexene 
• 180573-16-4 2-oxo-1-phenethylcyclohexanecarboxylic acid methyl ester 
• 10468-40-3 cyclohexanone N-cyclohexylimine 
• 5414-21-1 5-bromopentan-1-nitrile 
• 58749-30-7 (3-phenylpropane-1,1-diyl)bis(phenylsulfane) 

Downstream Products

• 144147-84-2 2-(2,2-Dimethoxy-acetyl)-6-phenethyl-cyclohexanone 
• 144149-53-1 (E)-3-[2-(4-Fluoro-phenyl)-7-phenethyl-4,5,6,7-tetrahydro-2H-indazol-3-yl]-propenal 
• 144148-29-8 2-(4-Fluoro-phenyl)-7-phenethyl-4,5,6,7-tetrahydro-2H-indazole-3-carbaldehyde 
• 199797-18-7 7-(2-phenethyl)-2-oxepanone 
• 36449-64-6 (+/-)-1-phenethyl-cyclohexanol-⁽²⁾ 

Relevant articles and documents

Carbolithiation of styrenes with N-tert-butyl aldimines

The addition of aldimine anions to styrene occurs upon the treatment of N-tert-butyl aldimine with LDA followed by the addition of styrene to give the corresponding aldehyde after hydrolysis. Cyclohexenyl amines are generated when the reactions are performed with unsaturated aldimines. This approach affords 4-phenyl substituted butanals and cyclohexenyl amines in a simple and inexpensive way.

α-alkylation of ketones by addition of zinc enamides to unactivated olefins

A zinc enamide generated from the corresponding N-aryl imine undergoes addition to an unactivated olefin, such as ethylene, 1-octene, and isobutylene, to generate an α-alkylated γ-zincioimine intermediate in good to excellent yield. Terminal and gem-disubstituted olefins react with >99% regioselectivity, allowing the C-C bond formation to take place at the more hindered carbon of the double bond. The organozinc intermediate undergoes further C-C bond formation with a carbon electrophile to give, upon hydrolysis of the imine, an α-alkylated ketone bearing a variety of functionalized primary, secondary, and tertiary alkyl groups.

Titanocene(II)-promoted desulfurizative acylation of thioacetals with alkanenitriles

Ketones were obtained in good yields by titanocene(II)-promoted reaction of thioacetals with alkanenitriles. The regioselective formation of α-substituted ketone was observed when the reaction was carried out in the presence of methyl iodide or benzyl bro