1138-58-5

Basic information

• Product Name: 4-(N-BUTOXY)BENZENESULPHONAMIDE
• Synonyms: 4-BUTOXYBENZENE-1-SULFONAMIDE;4-BUTOXYBENZENESULFONAMIDE;4-(N-BUTOXY)BENZENESULPHONAMIDE;IFLAB-BB F1084-0540;4-(N-BUTOXY)BENZENESULFONAMIDE;4-Butoxybenzenesulphonamide
• CAS NO: 1138-58-5
• Molecular Formula: C₁₀H₁₅NO₃S
• Molecular Weight: 229.3
• Mol File: 1138-58-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 102-104
• Boiling Point: 381.9 °C at 760 mmHg
• Flash Point: 184.8 °C
• Appearance: /
• Density: 1.194 g/cm³
• Vapor Pressure: 4.92E-06mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: 4-(N-BUTOXY)BENZENESULPHONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(N-BUTOXY)BENZENESULPHONAMIDE(1138-58-5)
• EPA Substance Registry System: 4-(N-BUTOXY)BENZENESULPHONAMIDE(1138-58-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 1138-58-5(Hazardous Substances Data)

Usage

General Description

4-(N-Butoxy)benzenesulphonamide is a chemical compound with the molecular formula C10H15NO3S. It is a sulfonamide derivative with a butoxy group attached to the benzene ring. 4-(N-BUTOXY)BENZENESULPHONAMIDE is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has potential applications as a herbicide, fungicide, and insecticide. 4-(N-Butoxy)benzenesulphonamide has also been studied for its antimicrobial properties and potential use as an antibacterial agent. Additionally, it may have applications in the field of material science and as a corrosion inhibitor.

InChI:InChI=1/C10H15NO3S/c1-2-3-8-14-9-4-6-10(7-5-9)15(11,12)13/h4-7H,2-3,8H2,1H3,(H2,11,12,13)

Upstream product

• 1126-79-0 n-butyl phenyl ether 
• 1138-56-3 4-butoxybenzene-sulfonyl chloride 
• 109-65-9 1-bromo-butane 
• 1576-43-8 4-hydroxybenzenesulphonamide 

Downstream Products

• 1326777-54-1 N-((4-butoxyphenyl)sulfonyl)-3',4'-dichloro-[1,1'-biphenyl]-3-carboxamide 
• 206065-86-3 5-((4-n-butoxybenzene)sulfonylcarbamoyl)-3-(2,4-dichlorobenzyl)-2-methylindole 
• 100862-37-1 N-(4-butoxy-benzenesulfonyl)-N'-propyl-urea 
• 91908-89-3 N-(4-butoxy-benzenesulfonyl)-N'-methyl-urea 
• 68668-50-8 (4-butoxy-benzenesulfonyl)-carbamic acid ethyl ester 

Relevant articles and documents

A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects

A series of benzene sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitors which incorporate lipophilic 4-alkoxy- and 4-aryloxy moieties, together with several derivatives of ethoxzolamide and sulfanilamide are reported. These derivatives were investi

Synthesis and cytotoxic evaluation of substituted sulfonyl-n- hydroxyguanidine derivatives as potential antitumor agents

A series of sulfonyl-N-hydroxygnanidine derivatives was designed and synthesized for cytotoxic evaluation as potential anticancer agents on the basis of the lead compound LY-181984. Replacement of the ureido moiety of the lead compound with hydrexyguanidine provided a stable cytotoxic agent. The conformation of sulfonyl-N-hydroxyguanidine derivatives, such as N-(4- chlorophenyl-)-N-[(benzo[2,3]thiadiazol-4-yl)sulfonyl]-N-hydroxyguanidine (4g), investigated utilizing HMBC NMR, theoretical calculations, and X-ray crystallography, indicated stacking of the two aromatic rings. The derivatives were evaluated for in vitro cytoxicity against five human tumor cell lines, including HepG2, TSGH 8302, COLO 205, KB, and MOLT-4. The cytotoxic activities of the derived compounds against the human tumor cell lines were equal to or greater than that of the lead compound. N-(4- Chlorophenyl)-N'-[[3,5-dichloro-4-(4-nitrophenoxy)phenyl]sulfonyl].N- hydroxyguanidine (4n) and N-(4-chlorophenyl)-N'-[[3,5-dichloro4-(2-chloro-4- nitrophenoxy)phenyl]sulfonyl]-N-hydroxyguanidine (40) exhibited the greatest growth inhibition of solid tumor cell lines. Compound 40 was found to possess antitumor activity against murine K1735/M2 melanoma xenografts.