1138247-25-2

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 18245-72-2 S-phenylthiopropionate 

Downstream Products

• 139348-13-3 S-phenyl (2R*,3S*)-3-hydroxy-2-methyl-3-<2-(trimethylsilyl)phenyl>propanethioate 
• 139348-13-3 S-phenyl (2R*,3R*)-3-hydroxy-2-methyl-3-<2-(trimethylsilyl)phenyl>propanethioate 
• 101765-69-9 (S)-2-{(2S,3S)-3-[1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-thiopropionic acid S-phenyl ester 
• 101765-69-9 (R)-2-{(2S,3S)-3-[1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-thiopropionic acid S-phenyl ester 
• 1138247-21-8 S-phenyl 3,3,3-trifluoro-2-methylpropanethioate 
• 1217744-93-8 S-phenyl 3,3,4,4,5,5,6,6,6-nonafluoro-2-methylhexanethioate 
• 1338366-89-4 C₃₁H₃₁NOS 
• 1239020-76-8 S-phenyl 5-hydroxy-2-methyloct-7-enethioate 
• 1051925-45-1 S-phenyl 5-cyano-2-methyl-5-(tritylamino)pentanethioate 
• 139348-13-3 S-phenyl 3-hydroxy-2-methyl-3-<2-(trimethylsilyl)phenyl>propanethioate 
• 139405-78-0 S-phenyl (-)-(2R,3S)-3-hydroxy-2-methyl-3-<2-(trimethylsilyl)phenyl>propanethioate 

Relevant academic research and scientific papers

Mechanistic studies on α-trifluoromethylation of ketones via silyl enol ethers and its application to other carbonyl compounds

(Chemical Equation Presented) Synthesis of α-CF3 carbonyl compounds has been recognized to be difficult up to now because the polarization of CF3δ--Iδ+ is opposite to that of CH3δ+-Iδ-, and this makes it difficult to introduce CF3+ unit to enolates. We recently reported an effective R-trifluoromethylation of ketones by using Et 2Zn with Rh catalyst, but the mechanism has not fully been cleared. Now, we carried out the detailed mechanistic studies and found the involvement of a highly reactive alkylrhodium complex which derived from Et2Zn and RhCl(PPh3)3 in this α-trifluoromethylation. Furthermore, this α-trifluoromethylation was applied to other types of carbonyl compounds in good yields.