1138406-45-7Relevant articles and documents
Rational design and structure-activity relationship studies of quercetin-amino acid hybrids targeting the anti-apoptotic protein Bcl-xL
Kellici, Tahsin F.,Chatziathanasiadou, Maria V.,Lee, Min-Sung,Sayyad, Nisar,Geromichalou, Elena G.,Vrettos, Eirinaios I.,Tsiailanis, Antonis D.,Chi, Seung-Wook,Geromichalos, George D.,Mavromoustakos, Thomas,Tzakos, Andreas G.
supporting information, p. 7956 - 7976 (2017/10/06)
Anti-apoptotic proteins, like the Bcl-2 family proteins, present an important therapeutic cancer drug target. Their activity is orchestrated through neutralization upon interaction of pro-apoptotic protein counterparts that leads to immortality of cancer
In vitro solubility, stability and permeability of novel quercetin-amino acid conjugates
Kim, Mi Kyoung,Park, Kwang-su,Yeo, Woon-seok,Choo, Hyunah,Chong, Youhoon
experimental part, p. 1164 - 1171 (2009/07/11)
In order to discover a quercetin prodrug with improved bioavailability, we synthesized nine quercetin-amion acid conjugates and estimated their pharmacokinetic properties including water solubility, stability against chemical or enzymatic hydrolysis, and