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Quercetin suppliers in China
Cas No: 117-39-5
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Big ordering quality guaranteed Quercetin 117-39-5 manufactory
Cas No: 117-39-5
No Data 1 Gram 10 Metric Ton/Month Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Quercetin
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USD $ 800.0-1000.0 / Kilogram 1 Kilogram 5000 Metric Ton/Day Kono Chem Co.,Ltd Contact Supplier
High Quality 99% Quercetin 117-39-5 GMP manufacturer
Cas No: 117-39-5
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Factory Directly Supply Sophora Japonica Extract Best Quercetin with Bulk Stocks in USA Bulk Supply Natural Extract Quercetin 95% Raw Powder High Purity Quercetin Dihydrate
Cas No: 117-39-5
USD $ 1.32-1.32 / Gram 10 Gram 100 Kilogram/Month Xi'an Faithful Biotech Co., Ltd. Contact Supplier
Organic Ginkgo Biloba Leaf Extract Natural Herbal
Cas No: 117-39-5
USD $ 50.0-100.0 / Kilogram 1 Kilogram 10 Metric Ton/Year FUYAN PHARM(HENAN) INC. Contact Supplier
Quercetin
Cas No: 117-39-5
No Data No Data No Data Cartoon Ingredients Co., Ltd Contact Supplier
onion extract
Cas No: 117-39-5
USD $ 10.0-10.0 / Kilogram 1 Kilogram 300 Kilogram/Month Greenutra Resource Inc Contact Supplier
High quality Quercetin supplier in China
Cas No: 117-39-5
No Data No Data Metric Ton/Day Simagchem Corporation Contact Supplier
Quercetin suppliers in China CAS NO.117-39-5
Cas No: 117-39-5
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier

117-39-5 Usage

Chemical Properties

It is yellow needle-like crystalline powder. It has good thermal stability with the decomposition temperature being 314 °C. It can improve the light-tolerance property of food pigment for preventing the change of the flavor of food. Its color will change in case of metal ion. It is slightly soluble in water, soluble in an alkaline aqueous solution. Quercetin and its derivatives is a kind of flavonoid compound which are widely present in a variety of vegetables and fruits such as onions, sea buckthorn, hawthorn, locust, tea. It has effects of anti-free radical, anti-oxidation, anti-bacterial, anti-viral as well as anti-allergic. For application in lard, its various antioxidant indicators are similar with that of BHA or PG. Because of the double bond between the 2,3 position as well as the two hydroxyl groups in 3 ', 4' , it has application of being used as a metal chelate or being the receptor of the free groups produced during the oxidation process of grease. In this case, it can be used as the antioxidants of ascorbic acid or grease. It also has a diuretic effect.

Chemical Properties

Yellow to green yellow crystalline powde

Biological Activity

Anti-tumor agent; induces apoptosis and inhibits synthesis of heat shock proteins. Inhibits many enzyme systems including tyrosine protein kinase, phospholipase A 2 , phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Can also activate Ca 2+ and K + channels and behaves as an agonist at estrogen (GPR30) receptors.

Uses

1. It can be used as a kind of antioxidant which is mainly used for oil, drinks, cold drinks, meat processing products. 2. It has good effects of expectorant, anti-cough, anti-asthma and can be used for treating chronic bronchitis as well as for adjuvant therapy of coronary heart disease and high blood pressure. 3. It can also be used as analytical standards

Reactivity Profile

3,3',4',5,7-Pentahydroxyflavone is a strong antioxidant and a metal chelator. Promotes the formation of nitrosamines .

Fire Hazard

Flash point data for 3,3',4',5,7-Pentahydroxyflavone are not available; however, 3,3',4',5,7-Pentahydroxyflavone is probably combustible.

Pharmacological effects

Quercetin can significantly inhibit the effect of cancer-promoting agent, inhibiting the growth of malignant cells in vitro, inhibiting the DNA, RNA, and protein synthesis of Ehrlich ascites tumor cells. Quercetin has effects of inhibiting the platelet aggregation and the release effect of serotonin (5-HT) as well as inhibiting the platelet aggregation process which is induced by ADP, thrombin and platelet-activating factor (PAF) in which having the strongest inhibition effect on PAF. Moreover, it can also inhibit thrombin-induced the release of platelet 3H-5-HT of rabbit. (1) Intravenously adding 0.5mmol/L quercetin (10ml/kg) drop wise can significantly shorten the duration of arrhythmia in mice of myocardial ischemia and reperfusion, reduce the incidence of ventricular fibrillation, and reduce the content of MDA as well as the activity of xanthine oxidase inside the ischemic myocardial tissue while having significantly protective effect on SOD. This may be related to the inhibition of the formation process of myocardial oxygen free radical and protection of SOD or directly scavenging of radical free oxygen in myocardial tissue. (2) Having in vitro assay with quercetin and rutin being together can disperse the platelet and thrombus adhered to the rabbit aorta endothelium with an EC50 of 80 and 500nmol/L, respectivly. In vitro assay of a concentration of quercetin at 50~500μmol/L has shown that it can improve cAMP level inside human platelet, enhance the PGI2-induced improvement of cAMP level of human platelet and inhibit the ADP-induced platelet aggregation. Quercetin at a concentration ranged from 2~50μmol/L has a concentration-dependent enhancement effect. Quercetin, at a concentration of 300 μmol/L in vitro can not only almost completely inhibit the process of platelet aggregation induced by platelet-activating factor (PAF), but also inhibit thrombin and ADP-induced platelet aggregation as well as inhibit the release of rabbit platelet 3H-5HT induced by thrombin; A concentration of 30 μmol/L can significantly reduce the liquidity of platelet membrane. (3) Quercetin, at a concentration at 4×10-5~1×10-1g/ml, has a inhibitory effect on the release of histamine and SRS-A in the lung of ovalbumin-sensitized guinea pig lung; A concentration of 1 × 10-5g/ml also has inhibitory effect on the for SRS-A induced ileum contraction of guinea pig. Quercetin, at a concentration of 5~50μmol/L, has a concentration-dependent inhibitory effect on the process of histamine release of human basophilic leucocyte. Its inhibitory effect on the ileum contraction of ovalbumin sensitized guinea pig is also concentration-dependent with an IC50 of 10μmol/L. A concentration in the range of 5×10-6~5×10-5mol L can inhibit the proliferation of cytotoxic T lymphocyte (CTL) as well as inhibit ConA-induced DNA synthesis.

Uses

Medicine, reported formation of epoxy resins on mixing with epichlorohydrin.

General Description

Yellow needles or yellow powder. Converts to anhydrous form at 203-207°F. Alcoholic solutions taste very bitter.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 3,3',4',5,7-Pentahydroxyflavone emits acrid smoke and irritating fumes.

Expectorants

Quercetin is commonly used as a expectorant drug in clinical medicine in China. This product has various kinds of pharmacological functions such as having a good expectorant, cough effect, also having certain anti-asthma effect, and having further effects of lowering blood pressure, enhancing capillary resistance, reducing capillary fragility, reducing blood fat, expansion of coronary artery, increasing coronary blood flow. Clinically, quercetin is mainly used for treating clinical bronchitis and phlegmatic inflammation. It also has adjuvant therapy effect on coronary artery disease and high blood pressure. FDA may have some kinds of adverse reactions such as dry mouth, dizziness, and burning sensation in stomach area which may disappear after treatment. Quercetin is widely distributed in angiosperms such as Threevein Astere, Golden Saxifrage, berchemia lineata, gold, rhododendron dauricum, seguin loquat, purple rhododendron, Rhododendron micranthum, Japanese Ardisia Herb and Apocynum. It is a kind of aglycon which mainly combines with carbohydrate to be in the form of glycosides, such as quercetin, rutin, hyperoside.

Production method

1. Crash the bark of trees in Fagaceae Quercus (Quercus) into powder, wash with hot brine, extract with dilute ammonia before neutralization with dilute sulfuric acid. Boil the filtrate and separate crystals. 2. It can be obtained by extracting Liliaceae onion (Alliumcepa) with 95% ethanol; it can also be produced from rutin (rutin) extract, quercetin, isoquercitrin, fennel glycosides, hyperoside, quercimeritrin, bloom glycosides through rutin degrading enzyme or hydrolysis with acidic aqueous solution.

Hazard

Questionable carcinogen.

Safety Profile

Poison by ingestion, subcutaneous, and intravenous routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Human mutation data reported. Used as a pharmaceutical and veterinary drug. When heated to decomposition it emits acrid smoke and irritating fumes

Air & Water Reactions

Sensitive to exposure to air and light. Insoluble in water.

117-39-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (Q4951)  Quercetin  ≥95% (HPLC), solid 117-39-5 Q4951-10G 444.60CNY Detail
Sigma (Q4951)  Quercetin  ≥95% (HPLC), solid 117-39-5 Q4951-100G 2,277.99CNY Detail

117-39-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name quercetin

1.2 Other means of identification

Product number -
Other names MELETIN

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food Additives: COLOUR
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:117-39-5 SDS

117-39-5Synthetic route

rutin
153-18-4

rutin

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With hydrogenchloride; methanol for 3h; Heating;96%
With water at 100℃; Kinetics; Ionic liquid;90%
With sulfuric acid; water at 20℃; for 0.166667h;89%
hydrogenchloride
7647-01-0

hydrogenchloride

quercetin triphenylantimony complex
187221-65-4

quercetin triphenylantimony complex

A

quercetol
117-39-5

quercetol

B

triphenylantimony dichloride
594-31-0, 34716-91-1, 20265-29-6

triphenylantimony dichloride

Conditions
ConditionsYield
heating (3 h, water bath); soln. pouring into Petri dish, solid extraction by benzene;A 75%
B 88%
6,8-dibromoquercetin
95412-48-9

6,8-dibromoquercetin

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With sodium sulfite In water at 60℃; for 18h; Green chemistry;87%
2-(3,4-dimethoxyphenyl)-3-hydroxy-5,7-dimethoxy-4H-4-chromenone
1244-78-6

2-(3,4-dimethoxyphenyl)-3-hydroxy-5,7-dimethoxy-4H-4-chromenone

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With boron tribromide In dichloromethane for 6h; Heating;83%
With trimethylsilyl iodide In methanol at 35℃; for 96h; Inert atmosphere;
Hyperoside
482-36-0

Hyperoside

A

D-Galactose
10257-28-0

D-Galactose

B

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With sulfuric acid at 100℃; for 1h;A n/a
B 68%
With grape snail enzymes
With rhamnodiastase
antoside

antoside

A

D-Glucose
2280-44-6

D-Glucose

B

L-rhamnose
73-34-7

L-rhamnose

C

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With sulfuric acid at 100℃; for 2h;A n/a
B n/a
C 68%
With sulfuric acid at 100℃; for 2h;A n/a
B n/a
C 47%
quercetin 7-O-β-D-glucopyranoside
491-50-9, 36450-05-2, 59985-52-3

quercetin 7-O-β-D-glucopyranoside

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
Acid hydrolysis;68%
With sulfuric acid for 1h; Heating;
quercetin 7-O-β-D-glucopyranoside
491-50-9, 36450-05-2, 59985-52-3

quercetin 7-O-β-D-glucopyranoside

A

D-glucose
50-99-7

D-glucose

B

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With water Acidic conditions;A n/a
B 65%
With water Acidic conditions;
isoquercetin
482-35-9

isoquercetin

A

D-Glucose
2280-44-6

D-Glucose

B

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With sulfuric acidA n/a
B 64.3%
Product distribution; object of study - products of acid hydrolysis;
With 2M HCl In hydrogenchloride at 90℃; for 1h; Product distribution; other reagent;
Hyperoside
482-36-0

Hyperoside

A

D-Galactose
59-23-4

D-Galactose

B

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With water Acidic conditions;A n/a
B 64%
Acidic conditions;
Acidic aq. solution;
isoquercetin
482-35-9

isoquercetin

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
Acidic conditions;63.3%
With oxonium
With hydrogenchloride; ethanol for 4h; Heating;
Hyperoside
482-36-0

Hyperoside

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
Acidic conditions;63.3%
Acid hydrolysis;
With hydrogenchloride In water for 0.5h; Reflux;
Conditions
ConditionsYield
With α-L-rhamnosyl-β-D-glucosidase from Aspergillus niger K2 in Pichia pastoris In aq. phosphate buffer; dimethyl sulfoxide at 35 - 100℃; for 24h; pH=5; Enzymatic reaction;A 63%
B n/a
With rhamnodiastase Reactivity; Enzymatic reaction;
With rutinosidase In water Enzymatic reaction;
coniferol
458-35-5

coniferol

rutin
153-18-4

rutin

A

C22H32O12

C22H32O12

B

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With α-L-rhamnosyl-β-D-glucosidase from Aspergillus niger In dimethyl sulfoxide at 35℃; for 8h; pH=5; Enzymatic reaction;A 60%
B n/a
3,3',4',5,7-pentahydroxy flavanone
215257-15-1

3,3',4',5,7-pentahydroxy flavanone

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With potassium pyrosulfite In ethanol at 100℃;50%
With pyridine; air for 20h; Heating;
rutin
153-18-4

rutin

A

L-Rhamnose
3615-41-6

L-Rhamnose

B

D-glucose
50-99-7

D-glucose

C

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With sulfuric acid; waterA n/a
B n/a
C 47%
With sulfuric acid
With hydrogenchloride; water In methanol at 100℃; for 2h;
3,7-dihydroxyflavone
492-00-2

3,7-dihydroxyflavone

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; for 72h;28%
p-hydroxyphenethyl alcohol
501-94-0

p-hydroxyphenethyl alcohol

rutin
153-18-4

rutin

B

quercetol
117-39-5

quercetol

C

2-(4-hydroxyphenyl)ethyl β-rutinoside

2-(4-hydroxyphenyl)ethyl β-rutinoside

Conditions
ConditionsYield
Stage #1: p-hydroxyphenethyl alcohol; rutin In methanol at 40℃; for 30h;
Stage #2: With water In methanol for 0.166667h; Reflux; regioselective reaction;
A n/a
B n/a
C 24%
tamarixetin
603-61-2

tamarixetin

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With water; hydrogen iodide; acetic anhydride at 150℃;
3,3'-di-O-methylquercetin
4382-17-6

3,3'-di-O-methylquercetin

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With water; hydrogen iodide at 150℃;
2-benzo[1,3]dioxol-5-yl-3-hydroxy-5,7-dimethoxy-chromen-4-one
859439-36-4

2-benzo[1,3]dioxol-5-yl-3-hydroxy-5,7-dimethoxy-chromen-4-one

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With aluminium trichloride; chlorobenzene at 130℃; Erwaermen des Reaktionsgemisches mit wss. HCl;
rhamnetin
90-19-7

rhamnetin

quercetol
117-39-5

quercetol

avicularin
572-30-5

avicularin

A

D-Arabinose
10323-20-3

D-Arabinose

B

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With hydrogenchloride for 2h; Heating;
isoquercetin
482-35-9

isoquercetin

A

β-D-glucose
492-61-5

β-D-glucose

B

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
Product distribution; acid hydrolysis;

A

L-rhamnose
73-34-7

L-rhamnose

B

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With hydrogenchloride
With sulfuric acid
quercetol
117-39-5

quercetol

acetic anhydride
108-24-7

acetic anhydride

3,5,7-triacetoxy-2-(3,4-diacetoxy-phenyl)-chromen-4-one
1064-06-8

3,5,7-triacetoxy-2-(3,4-diacetoxy-phenyl)-chromen-4-one

Conditions
ConditionsYield
With pyridine at 130 - 140℃;100%
With pyridine at 140 - 145℃; for 4h;97.5%
With pyridine at 70℃; for 6h;95%
quercetol
117-39-5

quercetol

C30H20O14Se

C30H20O14Se

Conditions
ConditionsYield
With hydrogenchloride; selenium(IV) oxide In ethanol; water at 60℃; for 12h; Inert atmosphere;99.2%
quercetol
117-39-5

quercetol

acetic anhydride
108-24-7

acetic anhydride

quercetin-3',4',5,7-tetraacetate
7622-90-4

quercetin-3',4',5,7-tetraacetate

Conditions
ConditionsYield
With magnesium In neat (no solvent) at 25℃; for 3.5h; Temperature;98%
quercetol
117-39-5

quercetol

glucosidase

glucosidase

isoquercetin
482-35-9

isoquercetin

Conditions
ConditionsYield
With 1% disodium hydrogen phosphate-sodium citrate; 35-40% glucosyltransferase at 40 - 45℃; Enzymatic reaction;97.2%
quercetol
117-39-5

quercetol

benzoyl chloride
98-88-4

benzoyl chloride

2-(3,4-bis(benzoyloxy)phenyl)-4-oxo-4H-chromene-3,5,7-triyl tribenzoate
120036-90-0

2-(3,4-bis(benzoyloxy)phenyl)-4-oxo-4H-chromene-3,5,7-triyl tribenzoate

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 3h;97%
With pyridine at 22 - 24℃; for 4h;92%
With pyridine at 60℃;56%
With sodium hydroxide
quercetol
117-39-5

quercetol

2-Methylpropionic anhydride
97-72-3

2-Methylpropionic anhydride

2-(3,4-bis(isobutyryloxy)phenyl)-4-oxo-4H-chromene-3,5,7-triyl tris(2-methylpropanoate)
102607-68-1

2-(3,4-bis(isobutyryloxy)phenyl)-4-oxo-4H-chromene-3,5,7-triyl tris(2-methylpropanoate)

Conditions
ConditionsYield
With pyridine for 2h; Reflux;97%
In pyridine Ambient temperature;0.43 g
quercetol
117-39-5

quercetol

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

3,3',4',5,7-penta-O-tert-butyldimethylsilylquercetin
265975-30-2

3,3',4',5,7-penta-O-tert-butyldimethylsilylquercetin

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 6h; silylation;97%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 5h;
quercetol
117-39-5

quercetol

benzyl bromide
100-39-0

benzyl bromide

2-[3,4-bis(phenylmethoxy)phenyl]-3,5,7-tris(phenylmethoxy)chromen-4-one
13157-90-9

2-[3,4-bis(phenylmethoxy)phenyl]-3,5,7-tris(phenylmethoxy)chromen-4-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 72h;95%
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 4h; Etherification;89%
Stage #1: quercetol; benzyl bromide With potassium carbonate In N,N-dimethyl-formamide at 20 - 70℃; for 15h;
Stage #2: With water In N,N-dimethyl-formamide at 20℃; for 1h;
80%
quercetol
117-39-5

quercetol

benzyl chloride
100-44-7

benzyl chloride

2-[3,4-bis(phenylmethoxy)phenyl]-3,5,7-tris(phenylmethoxy)chromen-4-one
13157-90-9

2-[3,4-bis(phenylmethoxy)phenyl]-3,5,7-tris(phenylmethoxy)chromen-4-one

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate at 20℃; for 35h; Inert atmosphere;95%
With tetrabutylammomium bromide; potassium carbonate In 1-methyl-pyrrolidin-2-one; acetone at 85 - 90℃; for 24h;93%
With potassium carbonate; Aethyl-dipropyl-benzyl-ammonium In N,N,N,N,N,N-hexamethylphosphoric triamide for 35h; Inert atmosphere;90%
With tetrabutylammomium bromide; potassium carbonate In 1-methyl-pyrrolidin-2-one; acetone at 75℃; for 24h; Inert atmosphere;87%
With potassium carbonate; N,N-dimethyl-formamide at 20℃; for 12h;15%
quercetol
117-39-5

quercetol

sodium acetate
127-09-3

sodium acetate

acetic anhydride
108-24-7

acetic anhydride

3,5,7-triacetoxy-2-(3,4-diacetoxy-phenyl)-chromen-4-one
1064-06-8

3,5,7-triacetoxy-2-(3,4-diacetoxy-phenyl)-chromen-4-one

Conditions
ConditionsYield
Reflux; Inert atmosphere;95%
ZnCl2(1,10-phenanthroline)
14049-94-6

ZnCl2(1,10-phenanthroline)

quercetol
117-39-5

quercetol

[(1,10-phenanthroline)Zn(Quercetin)Cl].3H2O

[(1,10-phenanthroline)Zn(Quercetin)Cl].3H2O

Conditions
ConditionsYield
With triethylamine In ethanol; water at 20℃; for 0.166667h; Inert atmosphere;94%
quercetol
117-39-5

quercetol

2-(3',4'-dihydroxybenzoyloxy)-4,6-dihydroxybenzoic acid
30048-34-1

2-(3',4'-dihydroxybenzoyloxy)-4,6-dihydroxybenzoic acid

Conditions
ConditionsYield
With oxygen; tetraethylammonium tosylate In N,N-dimethyl-formamide Mechanism; electrolysis at -1.0 V, Au electrode;93%
With MES buffer; quercetinase EC 1.31.11.24 In dimethyl sulfoxide for 1h; pH=6;
With recombinant quercetinase from Aspergillus japonicus; oxygen In aq. buffer at 40 - 60℃; for 360h; pH=5; Reagent/catalyst; pH-value; Enzymatic reaction;
(2,2'-bipyridyl)dichlorozinc(II)
14491-36-2

(2,2'-bipyridyl)dichlorozinc(II)

quercetol
117-39-5

quercetol

[(2,2'-bipyridine)Zn(Quercetin)Cl].3H2O

[(2,2'-bipyridine)Zn(Quercetin)Cl].3H2O

Conditions
ConditionsYield
With triethylamine In ethanol; water at 20℃; for 0.166667h; Inert atmosphere;92%
dichloro(1,10-phenanthroline) copper(II)
14783-09-6

dichloro(1,10-phenanthroline) copper(II)

quercetol
117-39-5

quercetol

[(1,10-phenanthroline)Cu(Quercetin)Cl].3H2O

[(1,10-phenanthroline)Cu(Quercetin)Cl].3H2O

Conditions
ConditionsYield
With triethylamine In ethanol; water at 20℃; for 0.166667h; Inert atmosphere;92%
quercetol
117-39-5

quercetol

1-deoxy-1-fluoro-α-D-glucose
2106-10-7

1-deoxy-1-fluoro-α-D-glucose

quercetin 7-α-O-glucoside

quercetin 7-α-O-glucoside

Conditions
ConditionsYield
With α-glucosidase from sulfolobus solfataricus In dimethyl sulfoxide at 45℃; for 2h; pH=9; Enzymatic reaction;92%
quercetol
117-39-5

quercetol

2-(3,4-dihydroxy-5-sulfophenyl)-3,5,7-trihydroxy-4H-benzopyran-4-one
31273-65-1

2-(3,4-dihydroxy-5-sulfophenyl)-3,5,7-trihydroxy-4H-benzopyran-4-one

Conditions
ConditionsYield
With sulfuric acid at 80℃; for 2h;90%
quercetol
117-39-5

quercetol

A

C15H7O16S3(3-)*3K(1+)
116097-14-4

C15H7O16S3(3-)*3K(1+)

B

quercetin-3,7,3',4'-tetrasulphate potassium
90332-36-8, 119560-46-2

quercetin-3,7,3',4'-tetrasulphate potassium

Conditions
ConditionsYield
With potassium acetate; tetra(n-butyl)ammonium hydrogensulfate; dicyclohexyl-carbodiimide In pyridine at 25℃; for 288h;A 89%
B n/a
Dichlorodiphenylmethane
2051-90-3

Dichlorodiphenylmethane

quercetol
117-39-5

quercetol

2-(2,2-diphenylbenzo[1,3]dioxol-5-yl)-3,5,7-trihydroxychromen-4-one
357194-03-7

2-(2,2-diphenylbenzo[1,3]dioxol-5-yl)-3,5,7-trihydroxychromen-4-one

Conditions
ConditionsYield
In diphenylether at 175℃; for 2h;89%
In diphenylether at 175℃; for 2h;89%
In diphenylether at 175℃; for 0.5h; Inert atmosphere; regioselective reaction;86%
ethanol
64-17-5

ethanol

quercetol
117-39-5

quercetol

2-(3,4-Dihydroxy-phenyl)-2-ethoxy-3,3,5,7-tetrahydroxy-chroman-4-one
102788-22-7

2-(3,4-Dihydroxy-phenyl)-2-ethoxy-3,3,5,7-tetrahydroxy-chroman-4-one

Conditions
ConditionsYield
With oxygen; copper dichloride at 20℃; for 10h;88%
With phosphate buffer at 80℃; for 7h; Irradiation;3 mg
With phosphate buffer at 30℃; for 4h; Irradiation; enzyme solution from red clover (leaves and stems);2 mg
quercetol
117-39-5

quercetol

ethyl iodide
75-03-6

ethyl iodide

2-(3,4-diethoxyphenyl)-3,5,7-triethoxy-4H-chromen-4-one
82547-07-7

2-(3,4-diethoxyphenyl)-3,5,7-triethoxy-4H-chromen-4-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 45℃; for 12h; Inert atmosphere;87%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 15h; Inert atmosphere;82%
With tetraethylammonium fluoride In N,N-dimethyl-formamide for 20h;70%
With potassium hydroxide
quercetol
117-39-5

quercetol

pivaloyl chloride
3282-30-2

pivaloyl chloride

2-(3,4-bis(pivaloyloxy)phenyl)-4-oxo-4H-chromene-3,5,7-triyl tris(2,2-dimethylpropanoate)

2-(3,4-bis(pivaloyloxy)phenyl)-4-oxo-4H-chromene-3,5,7-triyl tris(2,2-dimethylpropanoate)

Conditions
ConditionsYield
With pyridine for 2h; Reflux;87%
With pyridine for 16h; Ambient temperature;67%
quercetol
117-39-5

quercetol

6-bromo-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one

6-bromo-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one

Conditions
ConditionsYield
With bromine In 1,4-dioxane at 20 - 22℃; for 2h;86.1%
Stage #1: quercetol With N-Bromosuccinimide; sodium hydroxide In methanol; water at 20℃; for 0.166667h; Inert atmosphere; Green chemistry;
Stage #2: With hydrogenchloride; sodium dithionite In methanol; water at 20℃; Inert atmosphere; Green chemistry;
400 mg
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere
2: N-Bromosuccinimide / dichloromethane / -40 °C / Inert atmosphere
3: boron trichloride / dichloromethane; hexane / 2.5 h / -20 °C / Inert atmosphere; Reflux
View Scheme
With bromine In 1,4-dioxane at 24.84℃;
quercetol
117-39-5

quercetol

methyl iodide
74-88-4

methyl iodide

pentamethyl quercetin
1247-97-8

pentamethyl quercetin

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 35℃; for 12h; Inert atmosphere;86%
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 12h;84%
With potassium carbonate In acetone for 24h; Reflux;82%
quercetol
117-39-5

quercetol

3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl-2,5,6-D3)-4H-1-benzopyran-4-one-6,8-D2

3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl-2,5,6-D3)-4H-1-benzopyran-4-one-6,8-D2

Conditions
ConditionsYield
With boron trifluoride; [D3]phosphoric acid In water-d2 at 55℃; for 48h; deuteration;86%
Stage #1: quercetol With [D]-sodium hydroxide; platinum on activated charcoal; water-d2 at 130℃; for 9h; Inert atmosphere;
Stage #2: With formic acid at 130℃; for 1h; Inert atmosphere;
63%
C35H56O5
1186389-75-2

C35H56O5

quercetol
117-39-5

quercetol

C50H64O11
1186389-71-8

C50H64O11

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 60℃; Inert atmosphere;86%
dimethylsulfide
75-18-3

dimethylsulfide

quercetol
117-39-5

quercetol

retusin
1245-15-4

retusin

Conditions
ConditionsYield
With potassium hydroxide In water; acetone86%
quercetol
117-39-5

quercetol

L-proline
147-85-3

L-proline

quercetin L-proline cocrystals(1:2)

quercetin L-proline cocrystals(1:2)

Conditions
ConditionsYield
In ethanol at 50℃;85.5%

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Quercetin is one of the most prominent and widely studied flavonoids. Its oxidation has been previously investigated only indirectly by comparative analyses of structurally analogous compounds, e.g. dihydroquercetin (taxifolin). To provide direct evidence about the mechanism of quercetin oxidati...detailed

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