113903-98-3

Upstream product

• 1663-39-4 tert-Butyl acrylate 
• 352-34-1 4-fluoro-1-iodobenzene 
• 1262991-68-3 tert-butyl 2-(4-fluorophenyl)diazene-1-carboxylate 
• 1589517-78-1 tetra-n-butylammonium 4-fluorophenylazocarboxylate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 459-32-5 4-fluorocinnamic acid 
• 13565-08-7 4-fluorocinnamoyl chloride 
• 75-65-0 tert-butyl alcohol 
• 371-14-2 4-fluorophenylhydrazine 
• 459-57-4 4-fluorobenzaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 515179-19-8 2-(4-fluorophenyl)cyclopropanecarboxylic acid 
• 161711-27-9 (1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid 
• 1414778-86-1 (1R,2R)-2-(4-fluorophenyl)cyclopropanecarbonyl fluoride 
• 1414775-40-8 (1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid [(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylamide 
• 1414775-42-0 (1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid [(R)-cyclopropyl-(3-ethanesulfonylphenyl)methyl](6-trifluoromethylpyridin-3-ylmethyl)amide 
• 1414775-44-2 (1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid [(S)-cyclopropyl-(3-ethanesulfonylphenyl)methyl](6-trifluoromethylpyridin-3-ylmethyl)amide 
• 1363722-10-4 C₂₇H₂₈F₂O₃S 
• 1363722-21-7 C₂₇H₂₈F₂O₃S 
• 1032169-55-3 tert-butyl (3S)-3-{allyl[(R)-1-phenylethyl]amino}-3-(4-fluorophenyl)propanoate 

Relevant academic research and scientific papers

Pd and Ni complexes of a novel vinylidene β-diketimine ligand: Their application as catalysts in Heck coupling and alkyne trimerization

A β-diketimine ligand with vinylidene substitution at γ-carbon, CH2C(CH3CNAr)2 (Ar?=?2,6-diisopropylphenyl) (L2), was synthesized by treating β-diketimine H2C(CH3CNAr)2 with n-BuLi followed by paraformaldehyde. L2 formed the homobimetallic ether-bridged β-diketiminate complex [O{(CH2-β-diketiminate)Pd(OAc)}2] (1) with (PdOAc)2. It also gave complexes [L2PdCl2] (2) and [L2NiBr2] (3) when treated with PdCl2(CH3CN)2 and NiBr2(dimethoxyethane), respectively. All the compounds were characterized using 1H/13C NMR spectroscopy and single-crystal X-ray diffraction studies. The catalytic activity of Pd and Ni complexes 1, 2 and 3 was explored in Heck coupling and alkyne trimerization reactions and it was found that they are very good catalysts. The results are reported in detail.

Fabrication of Pd/CuFe2O4 hybrid nanowires: A heterogeneous catalyst for Heck couplings

The development of environmentally benign transformations is indispensable in organic synthesis. Herein, a hybrid heterogeneous catalyst, palladium(0) on copper ferrite nanowires, has been synthesized, characterized, and for the first time, employed in the Jeffrey Heck reaction between iodoarenes and allylic alcohols, and good to excellent yields have been obtained. In addition, the catalyst was found to be suitable for the usual Heck coupling. The nanocatalyst was recovered and reused up-to multiple runs without any noticeable loss of its catalytic activity.

RETRACTED ARTICLE: A Recycling-Free Nanocatalyst System: The Stabilization of in Situ-Reduced Noble Metal Nanoparticles on Silicone Nanofilaments via a Mussel-Inspired Approach

The recovery and reuse of costly nanocatalysts is an essential operation in modern nanocatalysis, and improvements in catalyst reusability can contribute significantly to the economic viability and sustainable development of nanocatalysis. Herein, starting with the application of a silicone nanofilament (SNF) coating on a target substrate, a mussel-inspired approach in the form of polydopamine (PDA) deposition on the SNF surface was used to form in situ-reduced Pd nanoparticles (Pd NPs) and to stabilize them on the SNFs. This PDA-mediated approach enabled a high integrity nanocatalyst system to be built on a free-standing SNF support while retaining the porosity in the original SNF architecture. The SNFs-Pd nanocomposites prepared as such were applied to the inside walls of laboratory chemical reactors and used as recycling-free nanocatalyst systems for Pd-catalyzed organic reactions without the laborious conventional catalyst recovery and redispersion processes. The SNFs-Pd catalyst system exhibited high activity and high selectivity in single and successive Heck coupling reactions; and a reusability as high as 90% was still possible in the 20th cycle. This mussel-inspired approach is highly versatile and can be applied to laboratory chemical reactors in different shapes, sizes, and configurations to scale up the nanocatalyst applications. Furthermore, the general utility of the chemistry involved allows this surface modification technique to apply to other supported noble metal (e.g., Ag, Au, and Pt) catalysts, thereby increasing the usability and the performance of nanocatalyst systems.

Bioactivity and structure-activity relationship of cinnamic acid esters and their derivatives as potential antifungal agents for plant protection

A series of cinnamic acid esters and their derivatives were synthesized and evaluated for antifungal activities in vitro against four plant pathogenic fungi by using the mycelium growth rate method. Structure-activity relationship was derived also. Almost all of the compounds showed some inhibition activity on each of the fungi at 0.5 mM. Eight compounds showed the higher average activity with average EC50 values of 17.4-28.6 μg/mL for the fungi than kresoxim-methyl, a commercial fungicide standard, and ten compounds were much more active than commercial fungicide standards carbendazim against P. grisea or kresoxim-methyl against both P. grisea and Valsa Mali. Compounds C1 and C2 showed the higher activity with average EC50 values of 17.4 and 18.5 μg/mL and great potential for development of new plant antifungal agents. The structure-activity relationship analysis showed that both the substitution pattern of the phenyl ring and the alkyl group in the alcohol moiety significantly influences the activity. There exists complexly comprehensive effect between the substituents on the phenyl ring and the alkyl group in the alcohol moiety on the activity. Thus, cinnamic acid esters showed great potential the development of new antifungal agents for plant protection due to high activity, natural compounds or natural compound framework, simple structure, easy preparation, low-cost and environmentally friendly.

Hydrogen Peroxide Promoted Mizoroki-Heck Reactions of Phenyldiazenes with Acrylates, Acrylamides, and Styrenes

Mizoroki-Heck reactions, which are well-known for aryldiazonium salts and which have recently been described for arylhydrazines, have now been extended to phenyldiazenes. In situ generation of phenyldiazenes from azocarboxylates allowed clean and selective reactions with styrenes, acrylates, and acrylamides using palladium(II) acetate in the presence of silver(I) acetate or hydrogen peroxide as oxidant. Hydrogen peroxide was thereby shown to be a cheap and broadly applicable alternative for the established palladium-silver(I) system.

Palladium-catalyzed Heck coupling of arylhydrazines via C-NHNH2 bond activation

A novel palladium-catalyzed Heck coupling reaction of arylhydrazines with olefins is described, which affords various styrenes with high efficiency. This transformation proceeds through a C-NHNH2 bond activation under mild conditions.

AMINE DERIVATIVES AS POTASSIUM CHANNEL BLOCKERS

The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

Efficient aqueous-phase heck reaction catalyzed by a robust hydrophilic pyridine-bridged bisbenzimidazolylidene-palladium pincer complex

The first efficient example of NHC-palladium pincer complex catalyzed aqueous Heck reaction with extremely low catalyst loading was realized without obvious hydrolysis of products by using a robust hydrophilic pyridine-bridged bisbenzimidazolylidene-palla