113906-79-9Relevant academic research and scientific papers
Hansch analysis of substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides as antimicrobial agents
Kumar, Pradeep,Narasimhan, Balasubramanian,Sharma, Deepika,Judge, Vikramjeet,Narang, Rakesh
experimental part, p. 1853 - 1863 (2009/09/30)
A series of substituted hydrazide derivatives have been synthesized and screened for their in vitro antimicrobial activities against five representative microorganisms. The results of antimicrobial study indicated that the presence of electron withdrawing groups on the benzoic acid moiety improved antimicrobial activity. Further, the presence of heterocyclic ring furan does not improve the antimicrobial activity of substituted hydrazides. To understand the relationship between physicochemical parameters and antimicrobial activity of substituted hydrazide derivatives, QSAR investigation was performed by the development of one-target and multi-target models. The multi-target model was found to be effective in describing the antimicrobial activity of substituted hydrazides in comparison to the one-target models. Further, it indicated the importance of the topological parameter, valence third order molecular connectivity index (3χv) and the electronic parameter, energy of highest occupied molecular orbital (HOMO) in describing the antimicrobial activity of substituted hydrazides.
Oxidative cyclization of N-acylhydrazones. Development of highly selective turn-on fluorescent chemodosimeters for Cu2+
Li, Ai-Fang,He, Hui,Ruan, Yi-Bin,Wen, Zhen-Chang,Zhao, Jin-Song,Jiang, Qiu-Ju,Jiang, Yun-Bao
experimental part, p. 193 - 200 (2009/04/07)
A series of N-acylhydrazones were synthesised and found to be "turn-on" fluorescent chemodosimeters for Cu2+. Among the tested transition metal ions such as Cu2+, Pb2+, Zn 2+, Cd2+, Hg2+, and Ni2+, a prominent fluorescence enhancement of up to 1000-fold was only observed for Cu2+ in acetonitrile (CH3CN). This was indicated by an onset of unprecedented structured emission. Detailed experiments established that the highly Cu2+ selective fluorescence enhancement resulted from an oxidative cyclization by Cu2+of the originally nonfluorescent N-acylhydrazones into highly fluorescent rigid 1,3,4-oxadiazoles, n-dope type blocks in optoelectronic materials. The chemodosimeters can be applied to sense Cu2+ at nM levels in CH3CN and sub-M levels in neutral aqueous environments, despite a slower response in the latter case. It is expected that these redox-based chemodosimeters might be of general applicability.
