37584-91-1

Upstream product

• 156462-67-8 furan-2-carboxylic acid (4-methyl-benzylidene)-hydrazide 
• 113906-79-9 N'-(furan-2-ylmethylene)-4-methylbenzohydrazide 
• 104-87-0 4-methyl-benzaldehyde 
• 3326-71-4 2-furoic acid hydrazide 

Relevant academic research and scientific papers

Oxidative cyclization of aromatic aldehyde n-acylhydrazones by bis(trifluoroacetoxy)iodobenzene

Aromatic aldehyde N-acylhydrazones were oxidized into 2,5-disubstituted 1,3,4-oxadiazoles with bis(trifluoroacetoxy)iodobenzene in CHCl3 or DMSO at room temperature in good to excellent yields. Copyright Taylor & Francis Group, LLC.

Oxidative cyclization of N-acylhydrazones. Development of highly selective turn-on fluorescent chemodosimeters for Cu2+

A series of N-acylhydrazones were synthesised and found to be "turn-on" fluorescent chemodosimeters for Cu2+. Among the tested transition metal ions such as Cu2+, Pb2+, Zn 2+, Cd2+, Hg2+, and Ni2+, a prominent fluorescence enhancement of up to 1000-fold was only observed for Cu2+ in acetonitrile (CH3CN). This was indicated by an onset of unprecedented structured emission. Detailed experiments established that the highly Cu2+ selective fluorescence enhancement resulted from an oxidative cyclization by Cu2+of the originally nonfluorescent N-acylhydrazones into highly fluorescent rigid 1,3,4-oxadiazoles, n-dope type blocks in optoelectronic materials. The chemodosimeters can be applied to sense Cu2+ at nM levels in CH3CN and sub-M levels in neutral aqueous environments, despite a slower response in the latter case. It is expected that these redox-based chemodosimeters might be of general applicability.

Oxidative cyclization of aldazines with bis(trifluoroacetoxy)iodobenzene

Symmetrical and unsymmetrical aldazines are efficiently converted to 2,5-disubstituted-1,3,4-oxadiazoles by oxidation with bis(trifluoroacetoxy) iodobenzene (BTI).

A simple one-pot procedure for the synthesis of 1,3,4-oxadiazoles

A new method of synthesis of the 2,5-disubstituted 1,3,4-oxadiazoles, which uses the reaction of N-acyl-aldehyde hydrazones with chloramine T is described. The title compounds are obtained in very good yields (85-96%).