113907-55-4Relevant academic research and scientific papers
Tin Powder-Promoted One-Pot Construction of α-Methylene-γ-lactams and Spirolactams from Aldehydes or Ketones, Acylhydrazines, and 2-(Bromomethyl)acrylate
Xu, Yanli,Huang, Danfeng,Wang, Ke-Hu,Ma, Junyan,Su, Yingpeng,Fu, Ying,Hu, Yulai
, p. 12224 - 12233 (2015)
A concise and efficient method for the synthesis of α-methylene-γ-lactams is developed from multicomponent one-pot reactions of aldehydes or ketones, hydrazides, and ethyl 2-(bromomethyl)acrylate promoted by tin powder. The reaction proceeds smoothly under mild reaction conditions without using any catalyst to give the corresponding products in high yields. α-Methylene-γ-spirolactams can also be prepared from cyclic ketones.
