113932-23-3

Upstream product

• 83-13-6 diethyl 2-phenylmalonate 

Downstream Products

• 26739-86-6 Phenylmalonsaeure-aethylester-dimethylamid 
• 7713-74-8 ethyl 3-(methylamino)-3-oxo-2-phenylpropanoate 
• 177543-39-4 ethyl 3-(3-morpholino-1H-inden-2-yl)-3-oxo-2-phenylpropionate 
• 1228457-80-4 ethyl (E)-5-methyl-3,4-dioxo-2,6-diphenylhex-5-enoate 
• 1392325-33-5 ethyl (E)-5-methyl-3,4-dioxo-2-phenylhept-5-enoate 
• 1392325-24-4 C₂₃H₃₃NO₄Si 
• 1176948-98-3 1-((6-chloropyridin-3-yl)methyl)-4-oxo-3-phenyl-4H-pyrido[1,2-a]pyrimidin-1-ium-2-olate 
• 36277-53-9 C₁₁H₁₀O₃ 
• 41951-10-4 2,N-diphenyl-malonamic acid 
• 259248-79-8 N,N-dimethyl-α-phenylmalonamic acid 
• 7713-73-7 N-methyl-α-phenylmalonamic acid 

Relevant academic research and scientific papers

Hydrogen-Bonding Assisted Catalytic Kinetic Resolution of Acyclic β-Hydroxy Amides

Enantioenriched acyclic α-substituted β-hydroxy amides are valuable compounds in chemical, material and medicinal sciences, but their enantioselective synthesis remains challenging. A catalytic kinetic resolution (KR) of such amides with selectivity factor(s) up to >200 is developed via enantioselective acylation of primary alcohol with N-heterocyclic carbene. An enhanced selectivity for the catalytic KR process is realized using cyclic tertiary amine as base additive. Diastereomeric transition state models for the process are proposed to rationalize the origin of enantioselectivity.

Synthetic method of tropicamide

The invention relates to a production method of chemical medicines and particularly relates to a synthetic method of tropicamide. The synthetic method comprises the steps of carrying out hydrolysis and acylation on the raw material, namely diethyl phenylmalonate, condensing diethyl phenylmalonate with N-ethyl-4-methylpyridine amine, and generating reduction reaction with hydroboron, so as to obtain tropicamide. The synthetic method has the beneficial effects that the raw material cost is low, the properties of an intermediate product are stable, impurities are few, the operation steps such aspurification are reduced, and the process is simplified; reaction conditions are safe and mild, extremely toxic substances are not introduced, and the industrial amplified production is promoted; andby optimizing the raw material ratio, the total yield of the reaction is increased to be 65% and is greatly increased, and the production cost is lowered.

Neutral nazarov-type cyclization catalyzed by palladium(0)

Joining the circle: The first Pd0 catalyzed Nazarov-type cyclization of diketoesters (see scheme) proceeds in 70 % to 95 % yield under strictly neutral pH conditions. Aryl substitution of the diketoesters is not required, so the reaction shows great versatility and can also proceed with aliphatic substrates. Copyright