41951-10-4

Upstream product

• 103-82-2 phenylacetic acid 
• 103-71-9 phenyl isocyanate 
• 60-29-7 diethyl ether 
• 1068-55-9 isopropylmagnesium chloride 
• 71-43-2 benzene 
• 113932-23-3 2-chlorocarbonyl-2-phenyl-acetic acid ethyl ester 
• 13049-41-7 1,1-dimethoxy-2-phenylethene 
• 17097-90-4 2-phenylmalonic acid monoethyl ester 
• 17229-74-2 2,4-diphenyl-2H-isoxazol-5-one 
• 20628-57-3 ethyl 2-(phenylcarbamoyl)-2-phenylacetate 

Downstream Products

• 5449-36-5 methyl 3-oxo-2-phenyl-3-(phenylamino)propanoate 

Relevant academic research and scientific papers

The chemistry of 5-oxodihydroisoxazoles. XX: Photolysis of 2,4-diphenylisoxazol-5(2H)-one: Evidence for singlet and triplet pathways

2,4-Diphenylisoxazol-5(2H)-one (2) has been photolysed in the presence of alcohols, amines and in inert solvents, and the products are shown to arise by two competitive singlet state photolytic processes. The minor pathway involves loss of carbon dioxide to give an imino carbene which is captured by nucleophiles: the major pathway involves isomerization to a ketene which is rapidly decarbonylated, and the resultant carbene captured by solvent. The presence of acetone or other triplet sensitizers induces a third competitive pathway involving triplet states.

The Chemistry of 5-Oxodihydroisoxazoles. XII. Trapping of Derived Ketenimines with Lithium Amides and Alkyllithiums

Isoxazolones unsubstituted at C 3 react with lithium amides or alkyllithiums to give ketenimines.The presence of an ethoxycarbonyl group at C 4 allows capture of this species by addition of a second equivalent of the lithiated species to give enolates which can be alkylated in situ.The presence of a phenyl group at C 4 gives a ketenimine which reacts intramolecularly in the presence of lithium amides, whereas alkyllithiums undergo addition in synthetically useful processes.

Malonamic acid derivatives as M1 selective muscarinic receptor antagonists

A series of malonamic acid esters with suitable amino alcohols, typical of antimuscarinic compounds, was synthesized and the affinities for the three pharmacologically defined muscarinic receptor subtypes, namely M1, M2 and M3/

General Synthetic Route to Malonamic Acids and 3-Thiomalonamic Acids. Amidations and Thioamidations of α Anions of Carboxylate Salts with Alkyl and Aryl Isocyanates and Isothiocyanates

Treatment of α anions of carboxylate salts 2 with alkyl or aryl isocyanates and isothiocyanates leads to substituted malonamic acids (4, X=O) and 3-thiomalonamic acids (4, X=S), respectively.Lithium naphthalenide is utilized as the base in the formation o