113953-97-2

Upstream product

• 77835-31-5 N-(tert-butoxycarbonyl)-1,5-diaminopentane hydrochloride 
• 113953-95-0 3-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butylamino]-propionic acid 
• 3598-60-5 4-phthalimidobutanal 
• 501-53-1 benzyl chloroformate 
• 121903-77-3 [5-(3-{Benzyloxycarbonyl-[4-(2,2,2-trichloro-ethoxycarbonylamino)-butyl]-amino}-propionylamino)-pentyl]-carbamic acid tert-butyl ester 
• 121903-74-0 N⁸-phthaloylputreanine hydrochloride 
• 121903-76-2 (5-{3-[(4-Amino-butyl)-benzyloxycarbonyl-amino]-propionylamino}-pentyl)-carbamic acid tert-butyl ester 
• 121903-75-1 Pht=Pua(Z)-OH 
• 113953-96-1 Boc->Cad<-Pua(Z)=Pht 
• 462-94-2 1,5-diaminopentane 
• 4587-33-1 N-(tert-butyloxycarbonyl)-L-asparagine p-nitrophenyl ester 
• 121903-78-4 (4-{[2-(5-Amino-pentylcarbamoyl)-ethyl]-benzyloxycarbonyl-amino}-butyl)-carbamic acid 2,2,2-trichloro-ethyl ester 

Downstream Products

• 113953-98-3 2,4-dibenzyloxyphenylacetyl-L-Asn->Cad<-Pua(Z)-Troc 
• 121903-84-2 2,4-dibenzyloxyphenylacetyl-L-Asn->Cad<-Pua(Z)-H 
• 121903-73-9 [4-({2-[5-((S)-2-Amino-3-carbamoyl-propionylamino)-pentylcarbamoyl]-ethyl}-benzyloxycarbonyl-amino)-butyl]-carbamic acid 2,2,2-trichloro-ethyl ester 

Relevant academic research and scientific papers

Total synthesis of nstx-3, spider toxin of Nephila maculata

A spider toxin NSTX-3 obtained from the venom of Papua New Guinean spider, Nephila maculata was synthesized in order to confirm its proposed structure and to supply the sample for the biological tests. The structure of NSTX-3 is now established as 2,4-dihydroxyphenylacetyl-L-Asn→Cad←Pua←L-Arg, where Cad stands for cadaverine and Pua for putreanine.

SYNTHESIS OF A NEW NEUROTOXIN NSTX-3 OF PAPUA NEW GUINEAN SPIDER

A new spider toxin NSTX-3 was chemically synthesized for confirmation of the proposed structure and use in the investigation of neuroscience.