113953-99-4

Upstream product

• 14611-34-8 N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginine 
• 121903-84-2 2,4-dibenzyloxyphenylacetyl-L-Asn->Cad<-Pua(Z)-H 
• 113978-98-6 dibenzyl-2,4-dihydroxyphenylacetic acid N-hydroxysuccinimide ester 
• 113954-15-7 (S)-N¹-(5-Amino-pentyl)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-succinamide 
• 174623-84-8 C₄₅H₅₂N₆O₁₁ 

Downstream Products

• 107288-22-2 NSTX-3 

Relevant academic research and scientific papers

An efficient and versatile synthesis of all structural types of acylpolyamine spider toxins

An efficient and versatile synthesis of acylpolyamine spider toxins of all structural types classified by extensive MS analysis has been achieved. By using 2-nitrobenzenesulfonamide as an effective activating and/or protecting group (the Nosyl strategy),

An efficient and versatile synthesis of acylpolyamine spider toxins

An efficient and versatile synthesis of acylpolyamine spider toxins was developed based on the structural classification of the Nephila and Nephilengys spider toxins using the 2-nitrobenzenesulfonamide protecting group. The naturally occurring toxins 1-5

Practical, convergent total synthesis of polyamine amide spider toxin NSTX-3

A practical, total synthesis of polyamine amide spider toxin NSTX-3, a potent glutamate receptor antagonist with potential as a neuroprotective agent, is reported. The unsymmetrical polyamine moiety was built by a conjugate addition to afford putreanine and regioselective acylation of L-asparaginyl-cadaverine.

Total synthesis of nstx-3, spider toxin of Nephila maculata

A spider toxin NSTX-3 obtained from the venom of Papua New Guinean spider, Nephila maculata was synthesized in order to confirm its proposed structure and to supply the sample for the biological tests. The structure of NSTX-3 is now established as 2,4-dihydroxyphenylacetyl-L-Asn→Cad←Pua←L-Arg, where Cad stands for cadaverine and Pua for putreanine.