113953-99-4Relevant articles and documents
An efficient and versatile synthesis of all structural types of acylpolyamine spider toxins
Nihei, Ken-ichi,Kato, Massuo J.,Yamane, Tetsuo,Konno, Katsuhiro
, p. 8335 - 8350 (2007/10/03)
An efficient and versatile synthesis of acylpolyamine spider toxins of all structural types classified by extensive MS analysis has been achieved. By using 2-nitrobenzenesulfonamide as an effective activating and/or protecting group (the Nosyl strategy),
Practical, convergent total synthesis of polyamine amide spider toxin NSTX-3
Blagbrough, Ian S.,Moya, Eduardo,Walford, Steven P.
, p. 551 - 554 (2007/10/02)
A practical, total synthesis of polyamine amide spider toxin NSTX-3, a potent glutamate receptor antagonist with potential as a neuroprotective agent, is reported. The unsymmetrical polyamine moiety was built by a conjugate addition to afford putreanine and regioselective acylation of L-asparaginyl-cadaverine.