113965-60-9

Upstream product

• 100-25-4 para-dinitrobenzene 
• 113981-43-4 sodium 2,6-dibromo-4-methylphenoxide 
• 350-46-9 4-Fluoronitrobenzene 
• 2432-14-6 3,5-dibromo-4-hydroxytoluene 
• 106-44-5 p-cresol 

Downstream Products

• 918945-88-7 3,5-dibromo-4-(4-nitro-phenoxy)-benzoic acid 
• 918945-85-4 methyl N-[4-(4-aminophenoxy)-3,5-dibromobenzoyl]glycinate 
• 918945-89-8 methyl N-[4-(4-nitrophenoxy)-3,5-dibromobenzoyl]glycinate 
• 957828-70-5 3,5-dibromo-4-(4-nitro-phenoxy)-benzoic acid methyl ester 
• 957828-48-7 4-(4-amino-phenoxy)-3,5-dibromo-benzoic acid methyl ester 

Relevant academic research and scientific papers

INDOLE DERIVATIVES AND THEIR USE AS THYROID RECEPTOR LIGANDS

The invention provides compounds of formula (I) or pharmaceutically acceptable esters, amides, solvates or salts thereof, including salts of such esters or amides, and solvates of such esters, amides or salts, (I) wherein R1, R2, R3, R4, R5, R6, Y and W are as defined in the specification. The invention also provides the use of such compounds in the treatment or prophylaxis of a condition that may be treated with a thyroid receptor agonist or partial agonist.

HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR

The invention provides Compounds of formula (I) or pharmaceutically acceptable esters, amides, solvates or salts thereof, including salts of such esters or amides, and solvates of such esters, amides or salts, wherein R3, R4, G, Y, W and R5 are as defined in the specification. The invention also provides the use of such Compounds in the treatment or Prophylaxis of a condition associated with a disease or disorder associated with thyroid receptor activity.

NOVEL PHARMACEUTICAL COMPOSITIONS

The invention provides the use of compounds of formula (I) or pharmaceutically acceptable esters, amides, solvates or salts thereof, including salts of such esters or amides, and solvates of such esters, amides or salts, for the manufacture of a medicament for the treatment or prophylaxis of a condition that may be treated with a thyroid receptor agonist or partial agonist wherein R1, R2, R3, R4, Y, W and R5 are as defined in the specification. The invention also provides compounds of formula (Ia) or pharmaceutically acceptable esters, amides, solvates or salts thereof, including salts of such esters or amides, and solvates of such esters, amides or salts, formula (Ia) wherein R1, R2, R3, R4, Y, W and R5 are as defined in the specification.

A NOVEL, SIMPLE METHOD FOR THE PREPARATION OF HINDERED DIPHENYL ETHERS

The displacement of the nitro group from substituted nitrobenzenes is used for the synthesis of diphenyl ethers. 1,4-Dinitrobenzene has been converted into a variety of hindered diphenyl ethers using 2,6-disubstituted phenoxides and studies show that the mechanism of formation of the ether (5a) is radical in nature.

Displacement of an Aromatic Nitro Group using Phenoxides

1,4-dinitrobenzene undergoes nucleophilic substitution with sodium phenoxide and several hindered 2,6-disubstituted phenoxides to afford diphenyl ethers.