113975-30-7

Basic information

• Product Name: 2-(TERT-BUTYL)-1-METHYL-1H-PYRROLO[2,3-B]PYRIDINE
• Synonyms: 2-(TERT-BUTYL)-1-METHYL-1H-PYRROLO[2,3-B]PYRIDINE
• CAS NO: 113975-30-7
• Molecular Formula: C12H16N2
• Molecular Weight: 188.27
• Mol File: 113975-30-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(TERT-BUTYL)-1-METHYL-1H-PYRROLO[2,3-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TERT-BUTYL)-1-METHYL-1H-PYRROLO[2,3-B]PYRIDINE(113975-30-7)
• EPA Substance Registry System: 2-(TERT-BUTYL)-1-METHYL-1H-PYRROLO[2,3-B]PYRIDINE(113975-30-7)

Safety Data

• Hazardous Substances Data: 113975-30-7(Hazardous Substances Data)

Upstream product

• 113975-27-2 3,3-dimethyl-1-<2-(methylamino)-3-pyridinyl>-2-butanone 
• 372-48-5 2-fluoropyridine 
• 113975-23-8 methyl(3-iodopyridin-2-yl)amine 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 113975-22-7 2-fluoro-3-iodopyridine 

Relevant articles and documents

Metalation/SRN1 Coupling in Heterocyclic Synthesis. A Convenient Methodology for Ring Functionalization

Lithiation, iodination, and fluorine substitution on 2-fluoropyridine gave 2-substituted 3-iodopyridines, which were further subjected to iodine SRN1 substitution by carbon, sulfur, and phosphorus nucleophiles.Iodine substitution by enolates on 2-amino-3-iodopyridines afforded ketones, which were further cyclized to various 1,2-disubstituted pyrrolopyridines. 2-Amino-3-iodo-, 3-amino-4-iodo, and 4-amino-3-iodopyridines were prepared by directed metalation of 2-, 3-, and 4-(pivaloylamino)pyridines.Substitution of iodine by enolates under SRN1 conditions and acidic cyclization led to various 2-substituted pyrrolo, --, and -pyridines in high yields.