1139884-44-8

Basic information

• Product Name: 4-(2-aminoethyl)-N-(benzyloxycarbonyl)phenylamine
• Synonyms: 4-(2-aminoethyl)-N-(benzyloxycarbonyl)phenylamine
• CAS NO: 1139884-44-8
• Molecular Weight: 270.331
• Mol File: 1139884-44-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(2-aminoethyl)-N-(benzyloxycarbonyl)phenylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-aminoethyl)-N-(benzyloxycarbonyl)phenylamine(1139884-44-8)
• EPA Substance Registry System: 4-(2-aminoethyl)-N-(benzyloxycarbonyl)phenylamine(1139884-44-8)

Safety Data

• Hazardous Substances Data: 1139884-44-8(Hazardous Substances Data)

Upstream product

• 40377-41-1 4-(2-(((methyl)carbonyl)amino)ethyl)aniline 
• 13472-00-9 p-Aminophenethylamine 
• 501-53-1 benzyl chloroformate 

Relevant articles and documents

Microwave-assisted protection of primary amines as 2,5-dimethylpyrroles and their orthogonal deprotection

Primary amines can be readily doubly protected as N-substituted 2,5-dimethylpyrroles. Although this protecting group is stable toward strong bases and nucleophiles, long reaction times are required for both the protection and deprotection steps, generally resulting in low deprotection yields. By employing microwave irradiation, protection and deprotection reaction times are dramatically reduced. Furthermore, deprotection with dilute hydrochloric acid in ethanol increases reaction yields. Diverse deprotection conditions have been developed in conjunction with microwave irradiation, so that protection as an N-substituted 2,5-dimethylpyrrole can be orthogonal to other standard amine protecting groups, such as tert-butyloxycarbonyl (Boc), carbobenzyloxy (Cbz), and 9-fluorenylmethyloxycarbonyl (Fmoc).

A method for the selective protection of aromatic amines in the presence of aliphatic amines

A simple and efficient procedure has been developed for the regioselective protection of aromatic amines in the presence of aliphatic amines. The method is general for the preparation of mono-N-Boc, -N-Cbz, -N-Fmoc or -N-Alloc aromatic amines in high yield without affecting the aliphatic amines. This approach is applicable to substituted (aminoalkyl)aniline compounds with different functionalities and was employed to supply gram quantities of the protected aniline product. Georg Thieme Verlag Stuttgart · New York.