40377-41-1

Basic information

• Product Name: N-[2-(4-aminophenyl)ethyl]acetamide
• CAS NO: 40377-41-1
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.231
• Mol File: 40377-41-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 421.8°C at 760 mmHg
• Flash Point: 208.9°C
• Density: 1.09g/cm³
• Vapor Pressure: 2.54E-07mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: N-[2-(4-aminophenyl)ethyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(4-aminophenyl)ethyl]acetamide(40377-41-1)
• EPA Substance Registry System: N-[2-(4-aminophenyl)ethyl]acetamide(40377-41-1)

Safety Data

• Hazardous Substances Data: 40377-41-1(Hazardous Substances Data)

Usage

General Description

"N-[2-(4-aminophenyl)ethyl]acetamide" is a chemical compound with the molecular formula C10H14N2O. It is an amide derivative of 4-aminophenylethylamine, with an acetamide group attached. N-[2-(4-aminophenyl)ethyl]acetamide has potential applications in pharmaceuticals and organic synthesis, as it has been studied for its possible therapeutic effects. It may also have uses in research and development for the creation of new drugs or other chemical compounds. However, as with any chemical, proper handling and safety precautions should be taken when working with "N-[2-(4-aminophenyl)ethyl]acetamide."

Upstream product

• 13472-00-9 p-Aminophenethylamine 
• 140-39-6 1-acetoxy-4-methylbenzene 
• 1202-66-0 N-acetyltyramine 
• 141-78-6 ethyl acetate 
• 64-04-0 phenethylamine 
• 877-95-2 methyl-N-(benzyl-methyl)-formamide 
• 172217-04-8 α,α,α-trifluoro-o-diacetotoluidide 
• 6270-07-1 N-<2-(4-nitrophenyl)ethyl>acetamide 

Downstream Products

• 1140067-25-9 4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine 
• 1139884-80-2 N-(allyloxycarbonyl)-4-(2-aminoethyl)phenylamine 
• 457631-44-6 4-(2-aminoethyl)-N-(tert-butoxycarbonyl)phenylamine 
• 863910-54-7 C₁₉H₁₇ClF₃N₅O₂ 
• 159417-92-2 4-<2-(acetamido)ethyl>-acetanilide 
• 159417-94-4 4-<2-(N-tert-butoxycarbonyl)aminoethyl>-2-nitroaniline 

Relevant articles and documents

Direct conversion of phenols into primary anilines with hydrazine catalyzed by palladium

Primary anilines are essential building blocks to synthesize various pharmaceuticals, agrochemicals, pigments, electronic materials, and others. To date, the syntheses of primary anilines mostly rely on the reduction of nitroarenes or the transition-metal-catalyzed Ullmann, Buchwald-Hartwig and Chan-Lam cross-coupling reactions with ammonia, in which non-renewable petroleum-based chemicals are typically used as feedstocks via multiple step syntheses. A long-standing scientific challenge is to synthesize various primary anilines directly from renewable sources. Herein, we report a general method to directly convert a broad range of phenols into the corresponding primary anilines with the cheap and widely available hydrazine as both amine and hydride sources with simple Pd/C as the catalyst.

Rapid and Selective Cleavage of Amide Groups at Neutral pH: Applications from Hyaluronic Acid to Small Molecules

During our investigation to find suitable conditions to prepare very high molecular weight partially de-acetylated hyaluronic acid (HA), we discovered a powerful new method to cleave amide bonds using hydroxylamine salts at neutral pH with remarkable sele

Design and synthesis of isoquinolines and benzimidazoles as RAF kinase inhibitors

RAF kinase plays a critical role in the RAF-MEK-ERK signaling pathway and inhibitors of RAF could be of use for the treatment of various cancer types. We have designed potent RAF-1 inhibitors bearing novel bicyclic heterocycles as key structural elements for the interaction with the hinge region. In both series exploration of the SAR was focussed on the substitution of the phenyl ring, which binds to the induced fit pocket. Overall, it was confirmed that incorporation of lipophilic substituents was needed for potent Raf inhibition and a number of potent analogues were obtained.