40377-41-1

Usage

Uses

Used in Pharmaceutical Industry:
N-[2-(4-aminophenyl)ethyl]acetamide is used as a potential therapeutic agent for its possible medicinal properties. It is being studied for its potential effects in treating various conditions, contributing to the development of new pharmaceuticals.
Used in Organic Synthesis:
In the field of organic synthesis, N-[2-(4-aminophenyl)ethyl]acetamide serves as a valuable intermediate or building block for the synthesis of more complex organic compounds, including other pharmaceuticals and specialty chemicals.
Used in Research and Development:
N-[2-(4-aminophenyl)ethyl]acetamide is utilized in research and development for the exploration of its chemical properties and potential applications. It aids scientists in understanding its behavior and reactivity, which can lead to the discovery of new drugs or chemical processes.

Upstream product

• 13472-00-9 p-Aminophenethylamine 
• 172217-04-8 α,α,α-trifluoro-o-diacetotoluidide 
• 64-04-0 phenethylamine 
• 1202-66-0 N-acetyltyramine 
• 141-78-6 ethyl acetate 
• 877-95-2 methyl-N-(benzyl-methyl)-formamide 
• 6270-07-1 N-<2-(4-nitrophenyl)ethyl>acetamide 
• 140-39-6 1-acetoxy-4-methylbenzene 

Downstream Products

• 863910-54-7 C₁₉H₁₇ClF₃N₅O₂ 
• 457631-44-6 4-(2-aminoethyl)-N-(tert-butoxycarbonyl)phenylamine 
• 1139884-80-2 N-(allyloxycarbonyl)-4-(2-aminoethyl)phenylamine 
• 1140067-25-9 4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine 
• 159417-92-2 4-<2-(acetamido)ethyl>-acetanilide 
• 159417-94-4 4-<2-(N-tert-butoxycarbonyl)aminoethyl>-2-nitroaniline 

Relevant academic research and scientific papers

Direct conversion of phenols into primary anilines with hydrazine catalyzed by palladium

Primary anilines are essential building blocks to synthesize various pharmaceuticals, agrochemicals, pigments, electronic materials, and others. To date, the syntheses of primary anilines mostly rely on the reduction of nitroarenes or the transition-metal-catalyzed Ullmann, Buchwald-Hartwig and Chan-Lam cross-coupling reactions with ammonia, in which non-renewable petroleum-based chemicals are typically used as feedstocks via multiple step syntheses. A long-standing scientific challenge is to synthesize various primary anilines directly from renewable sources. Herein, we report a general method to directly convert a broad range of phenols into the corresponding primary anilines with the cheap and widely available hydrazine as both amine and hydride sources with simple Pd/C as the catalyst.

METHOD FOR CLEAVING AMIDE BONDS

A method for cleaving amide bonds, comprising: a) providing a molecule comprising an amide group;b) reacting the molecule comprising an amide group with hydroxylamine (NH2OH) or a salt thereof to cleave the amide bond of the amide group.

Rapid and Selective Cleavage of Amide Groups at Neutral pH: Applications from Hyaluronic Acid to Small Molecules

During our investigation to find suitable conditions to prepare very high molecular weight partially de-acetylated hyaluronic acid (HA), we discovered a powerful new method to cleave amide bonds using hydroxylamine salts at neutral pH with remarkable sele

Chemoselective N-acetylation of primary aliphatic amines promoted by pivalic or acetic acid using ethyl acetate as an acetyl donor

The combination of pivalic or acetic acid as a promoter and EtOAc as a solvent and acetyl donor proved to be efficient for the chemoselective N-acetylation of primary aliphatic amines to afford the corresponding acetamides. We developed a simple and convenient approach, which requires mild reaction conditions. Competitive inter- and intramolecular reactions between aliphatic amines, alcohols, and aromatic amines were examined, and chemoselectivity was achieved by adjusting the conditions of the reaction.

Design and synthesis of isoquinolines and benzimidazoles as RAF kinase inhibitors

RAF kinase plays a critical role in the RAF-MEK-ERK signaling pathway and inhibitors of RAF could be of use for the treatment of various cancer types. We have designed potent RAF-1 inhibitors bearing novel bicyclic heterocycles as key structural elements for the interaction with the hinge region. In both series exploration of the SAR was focussed on the substitution of the phenyl ring, which binds to the induced fit pocket. Overall, it was confirmed that incorporation of lipophilic substituents was needed for potent Raf inhibition and a number of potent analogues were obtained.

AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES

Amidine derivative compounds of formula I as defined in the Specification having nitric oxide synthetase inhibitory activity as well as processes for the preparation of and compositions containing said compounds are described

The ortho-substituted N,N-diacetylaniline as a selective acetylating reagent

Selective acetylation of the less hindered amino group in the presence of the more hindered amino group with the use of 2-trifluoromethyl-N,N-diacetylaniline 2c is described. This acetylation with 2c yielded the corresponding less hindered monoacetamide exclusively, simply, conveniently, and in good yields.

HIGHLY SELECTIVE ACYLATION OF AMINES AND ALCOHOLS BY POLY(3-ACYL-2-OXAZOLONE)

Poly(3-acyl-2-oxazolone) serves as a convenient reagent for highly chemo- and regioselective acylation of polyamines, amino-alcohols and polyalcohols.