1139921-54-2Relevant academic research and scientific papers
Lewis acid promoted benzylic cross-couplings of pyridines with aryl bromides
Duez, Stephanie,Steib, Andreas K.,Manolikakes, Sophia M.,Knochel, Paul
supporting information; experimental part, p. 7686 - 7690 (2011/10/17)
Either ZnCl2, Sc(OTf)3, or BF3OEt 2 can promote the palladium-catalyzed arylation of methylpyridines and related heterocycles (see example). The complexation of the Lewis acid to the nitrogen atom in the heteroc
Highly enantioselective iridium-Catalyzed hydrogenation of 2-Benzylquinolines and 2-Functionalized and 2,3-disubstituted quinolines
Wang, Da-Wei,Wang, Xiao-Bing,Wang, Duo-Sheng,Lu, Sheng-Mei,Zhou, Yong-Gui,Li, Yu-Xue
supporting information; experimental part, p. 2780 - 2787 (2009/08/08)
The enantioselective hydrogenation of 2-benzylquinolines and 2-functionalized and 2,3-disubstituted quinohnes was developed by using the [Ir(COD)Cl]2/bisphosphine/I2 system with up to 96% ee. Moreover, mechanistic studies revealed the hydrogenation mechanism of quinoline involves a 1,4-hydride addition, isomerization, and 1,2-hydride addition, and the catalytic active species may be a Ir(III) complex with chloride and iodide.
