113994-45-9 Usage
Uses
Used in Pharmaceutical Industry:
O-Des[2-aminoethyl]-O-carboxymethyl-dehydroamlodipine is used as an active metabolite for the treatment of cardiovascular conditions. As a metabolite of Amlodipine, it contributes to the anti-hypertensive effects of the parent drug, helping to manage and reduce high blood pressure and other related cardiovascular issues.
Used in Research and Development:
In the field of pharmaceutical research and development, O-Des[2-aminoethyl]-O-carboxymethyl-dehydroamlodipine can be utilized as a subject for further investigation into its potential therapeutic applications, mechanisms of action, and possible improvements in drug delivery systems. This may lead to the development of new drugs or drug formulations with enhanced efficacy and safety profiles.
Used in Drug Delivery Systems:
Similar to Gallotannin, O-Des[2-aminoethyl]-O-carboxymethyl-dehydroamlodipine may also benefit from novel drug delivery systems to improve its bioavailability, delivery, and therapeutic outcomes. Researchers can explore the use of various organic and metallic nanoparticles as carriers for O-Des[2-aMinoethyl]-O-carboxyMethyl-dehydroaMlodipine, aiming to enhance its overall effectiveness in treating cardiovascular conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 113994-45-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,9,9 and 4 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 113994-45:
(8*1)+(7*1)+(6*3)+(5*9)+(4*9)+(3*4)+(2*4)+(1*5)=139
139 % 10 = 9
So 113994-45-9 is a valid CAS Registry Number.
113994-45-9Relevant academic research and scientific papers
EX VIVO METHODS FOR PREDICTING AND CONFIRMING IN VIVO METABOLISM OF PHARMACEUTICALLY ACTIVE COMPOUNDS
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Page/Page column 38; 39; 40, (2015/06/25)
Methods and compositions for the catalytic oxidation of pharmaceutically active compounds, and more particularly to ex vivo methods for predicting in vivo metabolism of pharmaceutically active compounds, including predicting in vivo interaction between two or more pharmaceutically active compounds.
Biotransformation of amlodipine. Identification and synthesis of metabolites found in rat, dog and human urine / confirmation of structures by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry
Beresford,Macrae,Alker,Kobylecki
, p. 201 - 209 (2007/10/02)
Metabolism of the dihydropyridine calcium antagonist (R,S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5 methoxycarbonyl-6-methyl-1,4-dihydropyridine (amlodipine) has been studied in animals and man using 14C-labelled drug. The metabolite patterns are complex; 18 metabolites have been isolated from rat, dog and human urine. Based on chromatographic and mass-spectral evidence, structures have been proposed for the main metabolites and confirmed by synthesis of unambiguous reference compounds.
