114-24-9

Basic information

• Product Name: 3-{2-({3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl}methyl)-4-methyl-5-[(Z)-(4-methyl-2,3-dihydro-5H-furo[2,3-b]pyrrol-5-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid
• CAS NO: 114-24-9
• Molecular Formula: C₃₃H₃₆N₄O₆
• Molecular Weight: 584.6621
• Mol File: 114-24-9.mol
• Article Data: 15

Chemical Properties

• Density: 1.36g/cm³
• Refractive Index: 1.665
• CAS DataBase Reference: 3-{2-({3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl}methyl)-4-methyl-5-[(Z)-(4-methyl-2,3-dihydro-5H-furo[2,3-b]pyrrol-5-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-{2-({3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl}methyl)-4-methyl-5-[(Z)-(4-methyl-2,3-dihydro-5H-furo[2,3-b]pyrrol-5-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid(114-24-9)
• EPA Substance Registry System: 3-{2-({3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl}methyl)-4-methyl-5-[(Z)-(4-methyl-2,3-dihydro-5H-furo[2,3-b]pyrrol-5-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid(114-24-9)

Safety Data

• Hazardous Substances Data: 114-24-9(Hazardous Substances Data)

Upstream product

• 35677-91-9 18-devinyl-18-(1-methoxyethyl)bilirubin 
• 635-65-4 bilirubin 
• 902268-70-6 biliverdin IXα 
• 69853-44-7 bilirubin 
• 19792-68-8 bilirubin dimethylester 
• 59614-72-1 18-devinyl-18-<1-(acetylthio)ethyl>bilirubin 
• 66735-42-0 3,3'-[2-(1-mercapto-ethyl)-3,7,13,18-tetramethyl-1,19-dioxo-17-vinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-diyl]-bis-propionic acid 
• 92735-37-0 2,17-bis-(2-chloroethyl)-21,24-dihydro-8,12-bis-(2-methoxycarbonylethyl)-3,7,13,18-tetramethylbilin-1,19-dione 
• 10035-62-8 α-biliverdin-IX dimethyl ester 
• 80575-27-5 18-Devinyl-18-(1-carboxymethylthio)ethyl-bilirubin-IXα 
• 114-25-0 3,18-diethenyl-1,19,22,24-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid 

Downstream Products

• 1451878-43-5 (Z)-2-(3-ethenyl-4-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)ethanamide 
• 902268-70-6 biliverdin IXα 

Relevant articles and documents

Effect of Serum Albumins from Several Mammals on the Photoisomerization of Bilirubin

ZZ-Bilirubin undergoes photoisomerization to configurational (ZE and EZ isomers) and structural (LR) isomers in buffered aqueous solution containing serum albumins.The efficiency and the course of the isomerization are very much dependent on the mammals from which serum albumins are taken.

Enzymatic degradation of heme. Oxygenative cleavage requiring cytochrome P-450.

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PRODUCTION OF RED BLOOD CELLS AND PLATELETS FROM STEM CELLS

This disclosure provides methods of making a megakaryocyte-erythroid progenitor cell (MEP), comprising differentiating a stem cell into a MEP in culture in the presence of an aryl hydrocarbon receptor (AhR) agonist. In some embodiments the stem cell is a pluripotent stem cell. In some embodiments the MEP co-expresses CD41 and CD235. In some embodiments the number of MEPs produced in the culture increases exponentially. Methods of making a red blood cell (RBC) by culturing a MEP in the presence of an AhR agonist are also provided. Methods of making a megakaryocyte and/or a platelet, comprising culturing a MEP in the presence of an AhR modulator are also provided. In some embodiments the AhR modulator is an AhR antagonist. This disclosure also provides compositions comprising at least 1 million MEPs per ml and compositions in which at least 50% of the cells are MEPs.

Effect of the Binding Sites of Human Serum Albumin on the Efficiency and Photostationary State Isomer Ratios of the Photoisomerization of Bilirubin

The quantum yields of the isomerization and photostationary state isomer ratios of the photoisomerization of (4Z,15Z)-bilirubin IXα (ZZ-BR) were determined in an aqueous buffered solution in the presence of human serum albumin (HSA) at a molar ratio of / from 0.5 to 2.The BR isomer compositions in the photostationary state were constant at /=0.5-0.7.With increasing / from 0.8 to 2, the ZZ-BR composition in the photostationary state increased from 58 to 75percent, but the ZE-BR composition decreased from 39 to 22percent.The quantum yields in the isomerization of ZZ-BR to ZE-BR (ΦZZ->ZE) and a cyclized product, lumirubin (LR), (ΦZZ->LR), remained unvaried up to /=1, but ΦZZ->ZE decreased while ΦZZ->LR increased along with a further increase of /.These results are explained by the existence of two binding sites, a first-class site and a second-class site, for bilirubin binding to HSA; ΦZZ->ZE in the second-class site (=0.035) was as low as 1/3 of that in the first-class site (=0.11), but ΦZZ->LR in the second-class site (=4.2*10-3) was nearly two-times higher than that in the first-class site (=2.4*10-3).