114029-41-3Relevant academic research and scientific papers
AMINO AND SUBSTITUTED AMINO PHOSPHINYL-ALKANOYL COMPOUNDS
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, (2008/06/13)
Compounds of the formula STR1 wherein X is an imino acid or ester and R 1 is hydrogen, STR2 are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
CARBOXYALKANOYL AND HYDROXYCARBAMOYLALKANOYL DERIVATIVES OF SUBSTITUTED PROLINES
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, (2008/06/13)
Compounds, compositions and method of alleviating hypertension using a compound of the formula STR1 wherein R is hydrogen or lower alkyl;R 1 is hydrogen, lower alkyl or phenyl-lower alkyl; R 2 is hydrogen, lower alkyl or phenyl lower alkyl or halo substituted lower alkyl;R 3 is hydroxy,--NHOH or lower alkoxy; Pr-COOR is a substituted proline of the structures STR2 R 4 is halogen, keto, azido, cycloalkyl, phenyl, substituted phenyl, phenyl-lower alkyl, substituted phenyl-lower alkyl, STR3 or Y--R 6 ; R 5 is hydrogen or lower alkyl;Y is oxygen or sulfur; R 6 is lower alkyl, phenyl, substituted phenyl, phenyl-lower alkyl, substituted phenyl-lower alkyl, 1-or 2-naphthyl, substituted 1-or 2-naphthyl, biphenyl, or substituted biphenyl; R. sub.7 is halogen or--Y--R. sub.8 ;R 8 is lower alkyl, phenyl, phenyl-lower alkyl substituted phenyl-lower alkyl, biphenyl, napthyl, or the R 8 groups join to complete an unsubstituted 5-or 6-membered ring or such ring wherein one or more carbon atoms are substituted by a lower alkyl or di(lower alkyl) group; R 9 is keto, phenyl, 2-or 4-hydroxyphenyl;n is 0 or 1; and salts thereof.
MERCAPTOACYL DERIVATIVES OF VARIOUS 4-SUBSTITUTED PROLINES
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, (2008/06/13)
This invention is directed to compounds of the formula STR1 and various intermediates therefore. The final products possess useful hypotensive activity.
