114033-52-2Relevant academic research and scientific papers
Syntheses and Gastric Acid Antisecretory Properties of the H2-Receptor Antagonist N-propyl>thienoisothiazol-3-amine 1,1-Dioxide and Related Derivatives
Santilli, Arthur A.,Scotese, Anthony C.,Morris, Robert L.,Schiehser, Guy A.,Teller, Daniel M.,et al.
, p. 1479 - 1486 (2007/10/02)
The synthesis and gastric acid antisecretory properties of several N-substituted thienoisothiazol-3-amine 1,1-dioxides and analogues are described.Two of the more potent compounds, N-propyl>thienoisothiazol-3-amine 1,1-dioxide (6a) and N-propyl>thienoisothiazol-3-amine 1,1-dioxide (6b), showed greater potencies as H2-receptor antagonist (in vitro) than ranitidine.They also had potent gastric acid antisecretory activities in vivo, inhibiting basal acid secretion in the rat (6a, 6b), histamine-stimulated acid secretion in the dog (6a, 6b), and food-stimulated acid secretion in the dog (6a).These were selected for further pharmacological evaluation.
