114095-02-2

Usage

Uses

Used in Pharmaceutical Industry:
IMIDAZO[2,1-B][1,3]BENZOTHIAZOL-2-YLMETHANOL is used as a key intermediate in the synthesis of bioactive molecules for the development of new drugs. Its unique structure and active properties make it a promising candidate for the creation of pharmaceuticals with potential applications in treating various diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical field, IMIDAZO[2,1-B][1,3]BENZOTHIAZOL-2-YLMETHANOL is used as a building block for the synthesis of bioactive compounds with potential applications in pest control, crop protection, and other agricultural areas. Its chemically active properties allow for the development of new agrochemicals that can improve crop yields and protect against harmful organisms.
Used in Materials Science:
IMIDAZO[2,1-B][1,3]BENZOTHIAZOL-2-YLMETHANOL is utilized as a component in the development of advanced materials with specific properties. Its heterocyclic structure contributes to the creation of materials with potential applications in various industries, such as electronics, sensors, and other high-tech fields.
Used in Anticancer Research:
IMIDAZO[2,1-B][1,3]BENZOTHIAZOL-2-YLMETHANOL has been studied for its potential anticancer activities, making it a promising candidate for further research and development in oncology. Its biologically active properties may contribute to the discovery of new anticancer drugs or therapies.
Used in Antiviral and Antimicrobial Research:
IMIDAZO[2,1-B][1,3]BENZOTHIAZOL-2-YLMETHANOL has also shown potential in antiviral and antimicrobial applications, making it a candidate for further exploration in the development of treatments for viral and bacterial infections. Its active properties could lead to the creation of new antiviral and antimicrobial agents to combat various diseases.

InChI:InChI=1/C10H8N2OS/c13-6-7-5-12-8-3-1-2-4-9(8)14-10(12)11-7/h1-5,13H,6H2

Upstream product

• 136-95-8 2-amino-benzthiazole 
• 21224-16-8 2-amino-6-ethylbenzo[d]thiazole 
• 64951-05-9 ethyl imidazo[2,1-b]-benzthiazole-2-carboxylate 

Downstream Products

• 114094-91-6 Benzo[d]imidazo[2,1-b]thiazol-2-yl-phenyl-methanone 
• 623906-22-9 4-nitrobenzyl 6-[(acetyloxy)(imidazo[2,1-b][1,3]benzothiazol-2-yl)methyl]-6-bromo-7-oxo-4-thia-1-azabicylco[3.2.0]hept-2-ene-2-carboxylate 
• 114095-04-4 2-formylimidazo[2,1-b]benzothiazole 

Relevant academic research and scientific papers

Discovery of novel Tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats

Tricyclic analogues were rationally designed as the high affinity niacin receptor G-protein-coupled receptor 109A (GPR109A) agonists by overlapping three lead structures. Various tricyclic anthranilide and cycloalkene carboxylic acid full agonists were di

Tricyclic 6-alkylidene-penems as class-D beta-lactamases inhibitors

This invention relates to certain tricyclic 6-alkylidene penems which act as a inhibitor of class-D enzymes. β-Lactamases hydrolyze β-lactam antibiotics, and as such serve as the primary cause of bacterial resistance. The compounds of the present inventio

Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum β-lactamase inhibitors: Crystallographic structures show unexpected binding of 1,4-thiazepine intermediates

The design and synthesis of a series of seven tricyclic 6-methylidene penems as novel class A and C serine β-lactamase inhibitors is described. These compounds proved to be very potent inhibitors of the TEM-1 and AmpC β-lactamases and less so against the class B metallo-β-lactamase CcrA. In combination with piperacillin, their in vitro activities enhanced susceptibility of all class C resistant strains from various bacteria. Crystallographic structures of a serine-bound reaction intermediate of 17 with the class A SHV-1 and class C GC1 enzymes have been established to resolutions of 2.0 and 1.4 A?, respectively, and refined to R-factors equal 0.163 and 0.145. In both β-lactamases, a seven-membered 1,4-thiazepine ring has formed. The stereogenic C7 atom in the ring has the R configuration in the SHV-1 intermediate and has both R and S configurations in the GC1 intermediate. Hydrophobic stacking interactions between the tricyclic C7 substituent and a tyrosine side chain, rather than electrostatic or hydrogen bonding by the C3 carboxylic acid group, dominate in both complexes. The formation of the 1,4- thiazepine ring structures is proposed based on a 7-endo-trig cyclization.

Process for preparing 6-alkylidene penem derivatives

The present invention provides a process of making compounds of formula I, which are useful for the treatment of bacterial infection or disease.

HETEROTRICYCLYL 6-ALKYLIDENE-PENEMS AS ΒΕΤΑ-LACTAMASE INHIBITORS

The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.

PROCESS FOR PREPARING 6-ALKYLIDENE PENEM DERIVATIVES

The present invention provides a process of making compounds of Formula (I), which are useful for the treatment of bacterial infection or disease.

(Imidazopyrimidin-2-yl)phenylmethanones and Related Compounds as Potential Nonsedative Anxiolytics

Several series of heterocyclic carboxylic esters were found to be active in the benzodiazepine receptor binding assay, a typical example being ethyl 7-ethyl-5-methoxyimidazoquinoline-2-carboxylate (4b) with an IC50 of 150 nM.The correspo