1140964-62-0Relevant academic research and scientific papers
Direct synthesis of primary arylamines via C-N cross-coupling of aryl bromides and triflates with amides
Romero,Harrak,Basset,Orúe,Pujol
, p. 1951 - 1956 (2009)
Aryl halides and triflates are coupled with primary amides to give the corresponding arylamines in the presence of a palladium catalyst, a suitable ligand, and a base. The catalyst system performs well for a large number of different substrates at 100-150 °C without solvent, and with low catalyst levels (0.12 mol % Pd). Nicotinamide might be useful as a nitrogen source in the Pd-catalyzed amination reaction.
