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Nicotinamide
Cas No: 98-92-0
No Data 1 Gram 1-1000 Metric Ton/Day Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Niacinamide 98-92-0 Vitamin B3 Nicotinamide
Cas No: 98-92-0
USD $ 29.0-29.0 / Kilogram 10 Kilogram 2000 Kilogram/Month ShangHai Soyoung Biotechnology Inc Contact Supplier
Nicotinamide
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USD $ 1.0-1.0 / Kilogram 25 Kilogram 3 Metric Ton/Day ZHEJIANG PAULA INDUSTRY CO.,LTD Contact Supplier
High quality niacinamide supplier in China
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No Data 25 Kilogram 2000 Metric Ton/Year Simagchem Corporation Contact Supplier
Good quality Nicotinamide//cas 98-92-0
Cas No: 98-92-0
No Data 25 Kilogram 200 Metric Ton/Month Hefei TNJ chemical industry co.,ltd Contact Supplier
Nicotinamide
Cas No: 98-92-0
No Data 25 Kilogram Metric Ton/Day HANGZHOU CLAKE BIOTECH CO.,LTD Contact Supplier
Factory Supply Vitamin B3 (Niacinamide)
Cas No: 98-92-0
USD $ 0.0-1.0 / Gram 100 Gram 36 Metric Ton/Day Ality Chemical Corporation Contact Supplier
pharma / food grade raw material API Nicotinamide USP in China
Cas No: 98-92-0
No Data 25 Kilogram 100 Metric Ton/Month Josun International Limited Contact Supplier
Nicotinamide
Cas No: 98-92-0
No Data No Data Metric Ton/Day Shanghai Yanchu chemicals Co., Ltd Contact Supplier
Niacinamide
Cas No: 98-92-0
No Data No Data No Data AmoyChem Co.,Ltd Contact Supplier

98-92-0 Usage

Uses

Niacinamide USP is used as food additive, for multivitamin preparations and as intermediate for pharmaceuticals and cosmetics.

Chemical Properties

It is white needle crystal or crystalline powder, no smell or odor slightly, slightly bitter taste. The relative density is 1.4, melting point is 131-132 ℃.1 g of the above the product is soluble in 1 ml of water, 1.5 ml ethanol or 10 ml glycerin, insoluble in ether. The pH of 10% aqueous solution is 6.5-7.5. in dry air to light and heat stability, in alkaline or acidic solution, heating generation to nicotinic acid. Rats by oral LD502.5-3.5g/kg ADI value does not make special provisions (ECC, 1990)

Uses

Same as nicotinic acid. Water soluble is better than niacin acid, easy to generate complex agglomerate with vitamin C. The dosage is 30-80 mg/kg.
Nicotinamide and nicotinic acid are in common use generally and nicotinic acid can transform into nicotinamide in animals. Lack of nicotinic acid and nicotinamide, results in pellagra. So they can prevent pellagra. They also play a role in the metabolism of protein and sugar, which can improve human and animal nutrition. In addition to be used as a medicine, it can also be applied in food and feed additives. The production capacity is more than 30000 tons in the world. In Japan, niacinamide used in medicine (40%), feed additives (50%) and food additives (10%). Nicotinic acid and nicotinamide are non-toxic, naturally contains in liver, kidney, yeast and honey. The niacinamide LD50 of subcutaneous injection for rat is 1.7 g/kg.
It is of Vitamin drugs, and involved in metabolic process. Can be used in skin care products, to prevent coarse skin, maintain healthy skin cells, and promote skin whitening. In addition, it can also be used in hair care products, to promote scalp blood circulation, healthy hair follicles, promotes hair growth and prevent alopecia.
Used in biochemical research. To prepare tissue culture medium. The pharmaceutical industry.

Definition

ChEBI: A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.

Reactivity Profile

An amine and amide. Acts as a weak base in solution. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

General Description

White powder.

Uses

A water-soluble vitamin B, incorporated within nicotinamide cofactors such as NADH and NADPH.

Air & Water Reactions

Water soluble.

Chemical Properties

White crystalline powder

Uses

Vitamin B3; enzyme cofactor; anti-pellagra

Toxicity

LD50 2.5~3.5 g/kg (rats, through the mouth).
GRAS(FDA,§182.5535,2000).
ADI is no special regulation (EEC, 1990).

description

Nicotinamide is also called vitamin B3 or vitamin PP, is a kind of water-soluble vitamin, belong to B vitamin, as NAD (nicotinamide adenine dinucleotide, NAD) and NADP (nicotinamide adenine dinucleotide phosphate, NADP) composition, hydrogenation and dehydrogenation properties of nicotinamide in the body part of this two kinds of structure of coenzyme the reversible, play a role of hydrogen delivery in biological oxidation, can promote tissue respiration, biological oxidation process and the new supersedes the old, having a great significance in maintaining normal tissue, especially the integrity of the skin digestive tract and the nervous system. When the lack of B vitamins, due to respiration and metabolism of cells affected by pellagra, so this product is mainly used for the prevention and treatment of pellagra, stomatitis, glossitis and so on. In addition, this product has prevention of heart block and improving the sinoatrial node and anti-fast experimental arrhythmia function, can significantly improve Vera Pammy induced bradycardia and atrioventricular block. The clinical for coronary heart disease, viral myocarditis, rheumatic heart disease and a handful of digitalis poisoning associated with arrhythmia (mostly applied only when other medications fail), generally the degree atrioventricular block has obvious curative effect, basically after the treatment, all block can disappear, has obvious curative effect in sick sinus syndrome, right bundle branch block effect is poor. After the stomach intestinal absorption by the oral, intramuscular absorption faster, then absorption distribution to the body tissues, t1/2 is 45 min. The liver metabolism, most metabolize N-n-methylnicotinamide, only a small amount of treatment as the prototype from the urine was more than necessary. If the daily urinary excretion of N-methyl nicotinamide is lower than 4mg, suggesting that nicotinamide deficiency.
Nicotinamide and nicotinic acid are collectively referred to vitamin PP, nicotinic acid in the animal body is involved in metabolic processes in the form of nicotinamide, both have a common vitamin activity. It is white crystalline powder, odorless or almost odorless, bitter taste, easily soluble in water or ethanol, soluble in glycerol. Hygroscopic weak stable., acid, alkali and high temperature. The nature mainly exists in cereal skin, yeast, peanuts, meat, animal organs, milk and green leafy vegetables, in the body it is from tryptophan synthesis, but the efficiency is very low. Escherichia coli in the intestine (Escherichia coli) can be converted into synthesis of nicotinic acid, nicotinamide. Prevention and treatment of pellagra, exposed parts of symmetric dermatitis, stomatitis, glossitis, anorexia, dermatitis, liver disease, coronary heart disease, atrioventricular block, sick sinus syndrome, diarrhea, neuritis and dementia.
[Adverse reaction] Occasionally dizziness, nausea, abdominal discomfort, loss of appetite, disappear on their own, in early pregnancy overdose possible teratogenic intramuscular injection can cause pain, so less.
The above information is Chemicalbook Hanya edited.

Synthesis

1.β-methyl pyridine is oxidized to nicotinic acid by air, and the latter is produced by the action of ammonium hydroxide, and then heating and dehydration.
2.Nicotinic acid, boric acid and ammonia into reaction pot, stirring at the condition of ammonia gas, heating dissolution; then distilled ammonia recovery, to 120℃ after the immigration dewatering pot continues to enrich; when the temperature reached 145 ℃, start adding liquid ammonia, and in 185 to 190℃ to ammonia reaction 20~30h. And then cooled to 130℃, diluted with distilled water, activated carbon was added, and in 70~80℃through ammonia decolorization 2h; reaction after filtered, , filtrate in 24 hours after analysis of cold water, fractional crystallization and washing with ethanol, and drying to obtain the finished product. The yield was 89%.
3. From the nicotinic acid and ammonia react into salt and then dehydrated.

Purification Methods

Crystallise niacin from *benzene. It has solubility in g/ml: H2O (1), EtOH (0.7) and glycerol (0.1). [Methods in Enzymology 66 23 1980, UV: Armarego Physical Methods in Heterocyclic Chemistry (Ed Katritzky, Academic Press) Vol III 83 1971, Beilstein 22 III/IV 389, 22/2 V 80.]
InChI:InChI=1/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

98-92-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (72345)  Nicotinamide  ≥98.5% (HPLC) 98-92-0 72345-1KG 1,055.34CNY Detail
Sigma-Aldrich (72345)  Nicotinamide  ≥98.5% (HPLC) 98-92-0 72345-250G 458.64CNY Detail
Sigma-Aldrich (72345)  Nicotinamide  ≥98.5% (HPLC) 98-92-0 72345-50G 277.29CNY Detail
Sigma (N3376)  Nicotinamide  ≥98% (TLC), powder 98-92-0 N3376-1KG 981.63CNY Detail
Sigma (N3376)  Nicotinamide  ≥98% (TLC), powder 98-92-0 N3376-500G 604.89CNY Detail
Sigma (N3376)  Nicotinamide  ≥98% (TLC), powder 98-92-0 N3376-100G 201.24CNY Detail
Supelco (47865-U)  Nicotinamide(Niacinamide)  analytical standard 98-92-0 47865-U 207.09CNY Detail
Cerilliant (V-016)  Nicotinamide (Vitamin B3) solution  1.0 mg/mL in methanol, ampule of 1 mL, certified reference material 98-92-0 V-016-1ML 716.04CNY Detail
USP (1462006)  Niacinamide  United States Pharmacopeia (USP) Reference Standard 98-92-0 1462006-500MG 4,581.72CNY Detail
Sigma-Aldrich (N0600000)  Nicotinamide  European Pharmacopoeia (EP) Reference Standard 98-92-0 N0600000 1,880.19CNY Detail
Sigma-Aldrich (PHR1033)  Niacinamide  pharmaceutical secondary standard; traceable to USP, PhEur and BP 98-92-0 PHR1033-1G 732.19CNY Detail
Alfa Aesar (A15970)  Nicotinamide, 99%    98-92-0 1000g 602.0CNY Detail

98-92-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-?Pyridinecarboxamide

1.2 Other means of identification

Product number -
Other names 3-Pyridinecarboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:98-92-0 SDS

98-92-0Synthetic route

pyridine-3-carbonitrile
100-54-9

pyridine-3-carbonitrile

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With manganese(IV) oxide; silica gel In hexane for 8h; Heating;100%
With manganese(IV) oxide; silica gel In chlorobenzene for 5h; Heating;100%
With water at 30℃; for 5.5h; Large scale reaction; Enzymatic reaction;99%
(1H-benzo[d][1,2,3]triazol-1-yl)(pyridin-3-yl)methanone
144223-30-3

(1H-benzo[d][1,2,3]triazol-1-yl)(pyridin-3-yl)methanone

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With ammonium hydroxide In tetrahydrofuran; ethanol at 20℃; for 4h;100%
3-Aminomethylpyridine
3731-52-0

3-Aminomethylpyridine

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With manganese(IV) oxide at 130℃; under 4560.31 Torr; for 3h;98%
With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); potassium tert-butylate In tert-butyl alcohol at 70℃; for 12h;96%
With oxygen; potassium carbonate; copper(I) bromide In water; dimethyl sulfoxide at 140℃; under 760.051 Torr; for 6h;90%
3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With C55H45ClN5P2Ru(1+)*Cl(1-); hydroxylamine hydrochloride; sodium carbonate In water at 110℃; for 12h; Sealed tube;95%
With C17H17BrClN2RuSe(1+)*F6P(1-); hydroxylamine hydrochloride; sodium hydroxide In toluene at 100℃; for 12h; Reagent/catalyst; Solvent; Temperature;91%
With hydroxylamine hydrochloride; methanesulfonyl chloride In neat (no solvent) at 70℃; for 3.5h;90%
thionicotinamide
4621-66-3

thionicotinamide

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With thionyl chloride; dihydrogen peroxide In ethanol at 25℃; for 0.0166667h;94%
With chloro-trimethyl-silane; dihydrogen peroxide In ethanol; water at 25℃; for 0.133333h; regioselective reaction;92%
With sodium hydroxide; copper(l) chloride In water; acetonitrile at 25℃; for 0.166667h;88%
With nitrosonium tetrafluoroborate In dichloromethane for 8h; Ambient temperature;74%
With potassium superoxide; 18-crown-6 ether for 1h; Ambient temperature;71%
nicotinamide N-oxide
1986-81-8

nicotinamide N-oxide

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With titanium tetrachloride; tin(ll) chloride In diethyl ether for 0.5h; Ambient temperature;93%
With indium; ammonium chloride In methanol; water for 5h; Reduction; Heating;91%
With molybdenum(V) chloride; sodium iodide In acetonitrile at 20℃; for 2h;91%
C22H27N5O15P2

C22H27N5O15P2

A

nicotinamide
98-92-0

nicotinamide

B

C16H21N3O14P2

C16H21N3O14P2

Conditions
ConditionsYield
With Aplysia cyclase at 23℃;A n/a
B 92%
3-iodopyridine
1120-90-7

3-iodopyridine

carbon monoxide
201230-82-2

carbon monoxide

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane; N-methoxylamine hydrochloride; sodium iodide; palladium dichloride In acetonitrile at 90℃; under 3800.26 Torr; for 8h; Autoclave; Inert atmosphere;92%
With 1,4-diaza-bicyclo[2.2.2]octane; palladium 10% on activated carbon; ammonium carbamate; potassium iodide In acetonitrile at 90℃; for 8h; Autoclave; Green chemistry;85%
3-Bromopyridine
626-55-1

3-Bromopyridine

potassiumhexacyanoferrate(II) trihydrate

potassiumhexacyanoferrate(II) trihydrate

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With potassium phosphate; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In water; dimethyl sulfoxide at 120℃; for 20h; Inert atmosphere; Sealed tube;92%
3-hydroxymethylpyridin
100-55-0

3-hydroxymethylpyridin

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With tert.-butylhydroperoxide; ammonia; oxygen In water; N,N-dimethyl-formamide at 80℃; under 1520.1 Torr; for 5h; Green chemistry;91%
With ammonium hydroxide; cryptomelane; oxygen In 1,4-dioxane at 130℃; under 2280.15 Torr; for 2h; Autoclave; Green chemistry;89%
Stage #1: 3-hydroxymethylpyridin With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; ammonia; oxygen; copper(II) nitrate In water; dimethyl sulfoxide at 80℃; under 760.051 Torr; for 5h;
Stage #2: With Acetaldehyde oxime In water; dimethyl sulfoxide at 110℃; for 24h; Inert atmosphere;
89%
3-Aminomethylpyridine
3731-52-0

3-Aminomethylpyridine

A

pyridine-3-carbonitrile
100-54-9

pyridine-3-carbonitrile

B

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With water; oxygen at 140℃; under 3800.26 Torr; for 24h;A n/a
B 90%
With ammonia; oxygen; vanadia at 375℃; Product distribution; other catalysts, effect of the presence of O2;
With ammonia In 1,4-dioxane; water at 130℃; under 4560.31 Torr; for 3h; Autoclave;A 7 %Chromat.
B 84 %Chromat.
nicotinamide guanine dinucleotide

nicotinamide guanine dinucleotide

A

nicotinamide
98-92-0

nicotinamide

B

cyclic-GDP-ribose

cyclic-GDP-ribose

Conditions
ConditionsYield
With phosphate buffer; Aplysia cyclase at 23℃; for 5h; pH=7.0;A n/a
B 90%
nicotinaldehyde oxime
51892-16-1

nicotinaldehyde oxime

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With aluminum oxide; water; methanesulfonyl chloride at 100℃; for 0.25h;90%
3-pyridinealdoxime
1193-92-6

3-pyridinealdoxime

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With C55H45ClN5P2Ru(1+)*Cl(1-) In water at 110℃; for 12h; Sealed tube;90%
With copper(II) acetate monohydrate In ethanol; acetonitrile for 5.5h; Time; Reflux;89.74%
With cis,cis,trans-[RuCl2{κ2-(P,N)-2-Ph2PC6H4CH=NOH}2] In water at 100℃; for 6h; Sealed tube; Inert atmosphere;86%
3-Bromopyridine
626-55-1

3-Bromopyridine

carbon monoxide
201230-82-2

carbon monoxide

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); (2R)-1-[(1R)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene; ammonium carbamate; sodium hydrogencarbonate In 1,4-dioxane at 100℃; for 20h; Inert atmosphere;89%
With 2-(2'-pyridyl)(di(1-adamantyl)phosphino)benzene; ammonia; palladium diacetate In 1,4-dioxane at 120℃; under 1500.15 Torr; for 16h; Autoclave;76%
With ammonia; palladium diacetate; catacxium A In 1,4-dioxane at 100℃; under 3000.3 Torr; for 16h; Autoclave;90 %Chromat.
With 1,1'-bis-(diphenylphosphino)ferrocene; ammonia; palladium diacetate In 1,4-dioxane at 100℃; under 1500.15 Torr; for 16h;94 %Chromat.
With ammonia; palladium diacetate; catacxium A In 1,4-dioxane at 100℃; under 1500.15 Torr; for 16h; Autoclave;
3-Bromopyridine
626-55-1

3-Bromopyridine

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With 1H-imidazole; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; ammonium chloride; N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 90℃; for 3h; Sealed tube;89%
nicotinic acid
59-67-6

nicotinic acid

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With ammonium cerium(IV) nitrate; urea for 0.025h; microwave irradiation;88%
With ammonium chloride; triethylamine at 20℃; for 0.0166667h;87%
Stage #1: nicotinic acid With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: With ammonium chloride In tetrahydrofuran; water at 0℃; for 0.5h;
84%
3-Methylpyridine
108-99-6

3-Methylpyridine

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With ammonium nitrate; oxygen at 120℃; under 37503.8 Torr; for 24h; Autoclave;83%
With tert.-butylhydroperoxide; cobalt ferrite; ammonium chloride; calcium carbonate In water; acetonitrile at 80℃; for 9h; Inert atmosphere; Green chemistry;53%
With manganese(IV) oxide; carbon dioxide; ammonia at 155℃; under 22502.3 Torr; for 3.5h; Temperature; Pressure;
nicotinamide hypoxanthine 5′-dinucleotide

nicotinamide hypoxanthine 5′-dinucleotide

A

nicotinamide
98-92-0

nicotinamide

B

cyclic-HDP-ribose

cyclic-HDP-ribose

Conditions
ConditionsYield
With phosphate buffer; Aplysia cyclase at 23℃; for 5h; pH=7.0;A n/a
B 81%
3-iodopyridine
1120-90-7

3-iodopyridine

potassium ferrocyanide

potassium ferrocyanide

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With water; potassium carbonate In dimethyl sulfoxide at 110℃; for 12h;81%
nicotinoyl azide
4013-72-3

nicotinoyl azide

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With thiamine diphosphate In methanol at 80℃; for 1h;80%
3-Chloropyridine
626-60-8

3-Chloropyridine

carbon monoxide
201230-82-2

carbon monoxide

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With (1,3-(dicyclohexylphosphino)propane )Pd(ethylene); ammonia; potassium carbonate In dimethyl sulfoxide at 110℃; under 450 Torr; for 24h; Schlenk technique; Inert atmosphere;77%
With ammonia; palladium diacetate; catacxium A In 1,4-dioxane at 130℃; under 3000.3 Torr; for 20h; Autoclave;40 %Chromat.
With 1,1'-bis-(diphenylphosphino)ferrocene; ammonia; palladium diacetate In 1,4-dioxane at 130℃; under 1500.15 Torr; for 20h;54 %Chromat.
3-ethylpyridine
536-78-7

3-ethylpyridine

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With tert.-butylhydroperoxide; ammonia; iodine In water at 100℃; for 3h; Sealed tube; Green chemistry;76%
pyridine-3-carbonitrile
100-54-9

pyridine-3-carbonitrile

formaldehyd
50-00-0

formaldehyd

A

N-hydroxymethylnicotinamide
3569-99-1

N-hydroxymethylnicotinamide

B

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With anion exchange resin AB-17-8 OH-form; ammonia; water at 60 - 90℃; for 1h;A 75.7%
B 23.2%
3-Bromopyridine
626-55-1

3-Bromopyridine

carbodiimide
151-51-9

carbodiimide

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride; magnesium chloride; zinc In N,N-dimethyl-formamide at 70℃; for 24h;75%
pyridine-3-carbonitrile
100-54-9

pyridine-3-carbonitrile

A

3-hydroxymethylpyridin
100-55-0

3-hydroxymethylpyridin

B

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With formaldehyd; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 In water; toluene at 90℃;A 21%
B 74%
1-nicotinoylpiperidine-2,6-dione

1-nicotinoylpiperidine-2,6-dione

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With lithium hydroxide monohydrate In water at 20℃; for 2h;74%
methyl-3-pyridylketone
350-03-8

methyl-3-pyridylketone

nicotinamide
98-92-0

nicotinamide

Conditions
ConditionsYield
With ammonia; water; iodine In tetrahydrofuran at 20℃; for 12h; Haller-Bauer reaction;69%
N-benzylnicotinamide
2503-55-1

N-benzylnicotinamide

A

nicotinamide
98-92-0

nicotinamide

B

benzaldehyde
100-52-7

benzaldehyde

Conditions
ConditionsYield
With N-Bromosuccinimide In chloroform at 20℃; for 20h; Product distribution;A 63%
B n/a
nicotinamide
98-92-0

nicotinamide

benzyl bromide
100-39-0

benzyl bromide

3-(aminocarbonyl)-1-benzylpyridinium bromide
13076-43-2

3-(aminocarbonyl)-1-benzylpyridinium bromide

Conditions
ConditionsYield
In acetone for 12h; Reflux;100%
In acetonitrile93%
In acetonitrile at 140℃; for 1.5h; Sealed tube; Microwave irradiation;89%
methanol
67-56-1

methanol

nicotinamide
98-92-0

nicotinamide

methyl-3-pyridyl carbamate
6269-24-5

methyl-3-pyridyl carbamate

Conditions
ConditionsYield
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; mercury(II) diacetate In N,N-dimethyl-formamide for 12h; Ambient temperature; or AgOAc;100%
With aluminum oxide; potassium fluoride; sodium hypochlorite In water for 0.5h; modified Hofmann rearrangement; Heating;90%
Stage #1: nicotinamide With trichloroisocyanuric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene at 20℃; Hofmann rearrangement; Inert atmosphere;
Stage #2: methanol at 65℃; Hofmann rearrangement; Inert atmosphere;
84%
With potassium hydroxide; [bis(acetoxy)iodo]benzene 1) 5-10 deg C, 15 min, 2) to r. t., 45 min;82%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

nicotinamide
98-92-0

nicotinamide

N,N-bis(trimethylsilyl)nicotinamide
69688-12-6

N,N-bis(trimethylsilyl)nicotinamide

Conditions
ConditionsYield
With 1,1,1,3,3,3-hexamethyl-disilazane at 150℃; for 12h;100%
With 1,1,1,3,3,3-hexamethyl-disilazane at 120℃; for 5h;
nicotinamide
98-92-0

nicotinamide

3,5-di-O-benzoyl-D-ribofuranosyl chloride
63592-86-9

3,5-di-O-benzoyl-D-ribofuranosyl chloride

3-Carbamoyl-1-(3,5-di-O-benzoyl-β-D-ribofuranosyl)-pyridiniumchlorid
23110-99-8

3-Carbamoyl-1-(3,5-di-O-benzoyl-β-D-ribofuranosyl)-pyridiniumchlorid

Conditions
ConditionsYield
100%
nicotinamide
98-92-0

nicotinamide

ascorbic acid
50-81-7

ascorbic acid

ascorbic acid,nicotinamide
114374-92-4

ascorbic acid,nicotinamide

Conditions
ConditionsYield
In water pH=Ca. 3.3 - 3.9; Cooling with ice;100%
In methanol33%
trimethylsilyl trifluoromethanesulfonate
27607-77-8

trimethylsilyl trifluoromethanesulfonate

nicotinamide
98-92-0

nicotinamide

1,2,3,5-tetraacetylribose
13035-61-5

1,2,3,5-tetraacetylribose

3-carbamoyl-1-((2R,3R,4R,5R)-3,4-diacetoxy-5-(acetoxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium trifluoromethanesulfonate

3-carbamoyl-1-((2R,3R,4R,5R)-3,4-diacetoxy-5-(acetoxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium trifluoromethanesulfonate

Conditions
ConditionsYield
Stage #1: nicotinamide; 1,2,3,5-tetraacetylribose In acetonitrile at 20℃;
Stage #2: trimethylsilyl trifluoromethanesulfonate In acetonitrile for 0.333333h;
100%
Stage #1: nicotinamide; 1,2,3,5-tetraacetylribose With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane In acetonitrile
Stage #2: trimethylsilyl trifluoromethanesulfonate In acetonitrile at 20℃; Reagent/catalyst;
Stage #1: trimethylsilyl trifluoromethanesulfonate; nicotinamide In acetonitrile for 0.0833333h;
Stage #2: 1,2,3,5-tetraacetylribose In acetonitrile at 20℃; for 0.5h; Inert atmosphere;
In acetonitrile at -5℃; for 8h; Inert atmosphere;19 g
nicotinamide
98-92-0

nicotinamide

4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

N-(4-(trifluoromethyl)phenyl)nicotinamide
25617-45-2

N-(4-(trifluoromethyl)phenyl)nicotinamide

Conditions
ConditionsYield
With C33H37N4P; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In tert-butyl alcohol at 95℃; for 5h; Inert atmosphere; Sonication;99.4%
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; potassium carbonate In 1,4-dioxane at 90℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere; Glovebox;91%
With C33H37N4P; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In tert-butyl alcohol at 95℃; for 5h; Inert atmosphere; Sonication;
nicotinamide
98-92-0

nicotinamide

pyridine-3-carbonitrile
100-54-9

pyridine-3-carbonitrile

Conditions
ConditionsYield
With N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide; copper(l) chloride In toluene at 100℃; for 24h;99%
With 3 A molecular sieve at 150 - 500℃; under 0.001 Torr; for 0.666667h; Pyrolysis;98%
With oxalyl dichloride; triethylamine; Triphenylphosphine oxide In acetonitrile at 20℃; for 0.166667h;96%
3-Chloropyridine
626-60-8

3-Chloropyridine

nicotinamide
98-92-0

nicotinamide

N-(pyridin-3-yl)pyridine-3-carboxamide
13160-06-0

N-(pyridin-3-yl)pyridine-3-carboxamide

Conditions
ConditionsYield
With 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; potassium phosphate; water; palladium diacetate In tert-butyl alcohol at 110℃; for 3h; Inert atmosphere;99%
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) In tert-butyl alcohol at 110℃; for 24h;97%
potassium tetrachloroplatinate(II)
10025-99-7

potassium tetrachloroplatinate(II)

nicotinamide
98-92-0

nicotinamide

Pt(C5H4NCONH2)4(2+)*2Cl(1-) = [Pt(C5H4NCONH2)4]Cl2

Pt(C5H4NCONH2)4(2+)*2Cl(1-) = [Pt(C5H4NCONH2)4]Cl2

Conditions
ConditionsYield
In water99%
nicotinamide
98-92-0

nicotinamide

5-azacytidine
320-67-2

5-azacytidine

5-azacytidine nicotinamide

5-azacytidine nicotinamide

Conditions
ConditionsYield
In methanol; water for 0.333333h;99%
nicotinamide
98-92-0

nicotinamide

1-(pyridin-3-yl)urea
13114-65-3

1-(pyridin-3-yl)urea

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene; ammonia In methanol at 0 - 20℃; for 2h; Hofmann Rearrangement; Inert atmosphere;99%
diethylstilbestrol
56-53-1

diethylstilbestrol

nicotinamide
98-92-0

nicotinamide

C18H20O2*C6H6N2O

C18H20O2*C6H6N2O

Conditions
ConditionsYield
In methanol at 50℃;98.62%
(1R,2S,5R)-1-(chloromethoxy)-2-isopropyl-5-methylcyclohexane
26127-08-2

(1R,2S,5R)-1-(chloromethoxy)-2-isopropyl-5-methylcyclohexane

nicotinamide
98-92-0

nicotinamide

3-carbamoyl-1-[(1R,2S,5R)-(-)-menthoxymethyl]pyridinium chloride

3-carbamoyl-1-[(1R,2S,5R)-(-)-menthoxymethyl]pyridinium chloride

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; Menschutkin quaternization;98.5%
nicotinamide
98-92-0

nicotinamide

nipecotamide
4138-26-5

nipecotamide

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In isopropyl alcohol at 75℃; under 3750.38 Torr; for 4h;98.4%
With hydrogen; Rh on carbon In water at 80℃; under 3800 Torr; for 1.5h;97%
With 10% Rh/C; hydrogen In water at 80℃; under 3800.26 Torr; for 1.5h;97%
nicotinamide
98-92-0

nicotinamide

nicotinamide N-oxide
1986-81-8

nicotinamide N-oxide

Conditions
ConditionsYield
With dihydrogen peroxide; VxSi4xO6.4x In acetonitrile at 80℃; for 3h;98%
With 2,2,2-Trifluoroacetophenone; dihydrogen peroxide; acetonitrile In tert-butyl alcohol at 20℃; for 18h; Green chemistry; chemoselective reaction;95%
With 1,2-diphenyl-1,1,2,2-tetrahydroperoxyethane In acetonitrile at 20℃; for 0.233333h;87%
S-Ethenyl-S-(4-methylphenyl)-N-tolylsulfilimine
64648-13-1, 81115-85-7, 81115-90-4

S-Ethenyl-S-(4-methylphenyl)-N-tolylsulfilimine

nicotinamide
98-92-0

nicotinamide

2-(pyridin-3-yl)-4,5-dihydrooxazole
40055-37-6

2-(pyridin-3-yl)-4,5-dihydrooxazole

Conditions
ConditionsYield
With sodium hydride In 1,2-dimethoxyethane at 20 - 40℃; for 29h;98%
1-chloromethoxy-heptane
49791-06-2

1-chloromethoxy-heptane

nicotinamide
98-92-0

nicotinamide

3-carbamoyl-1-heptyloxymethyl-pyridinium; chloride

3-carbamoyl-1-heptyloxymethyl-pyridinium; chloride

Conditions
ConditionsYield
at 20℃; for 1h;98%
1-chloromethoxy-nonane
24566-91-4

1-chloromethoxy-nonane

nicotinamide
98-92-0

nicotinamide

3-carbamoyl-1-nonyloxymethyl-pyridinium; chloride

3-carbamoyl-1-nonyloxymethyl-pyridinium; chloride

Conditions
ConditionsYield
at 20℃; for 1h;98%
1-trifluoromethanesulfonyloxy-4-t-butylcyclohexene
77412-96-5

1-trifluoromethanesulfonyloxy-4-t-butylcyclohexene

nicotinamide
98-92-0

nicotinamide

N-(4-tert-butylcyclohexen-1-yl)nicotinamide

N-(4-tert-butylcyclohexen-1-yl)nicotinamide

Conditions
ConditionsYield
With potassium carbonate; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium (0) In tert-butyl alcohol at 80℃; for 24h;98%
isoquinoline
119-65-3

isoquinoline

nicotinamide
98-92-0

nicotinamide

dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

C21H19N3O5

C21H19N3O5

Conditions
ConditionsYield
In dichloromethane at 20℃; for 24h;98%
nicotinamide
98-92-0

nicotinamide

1-(2-bromomethylbenzyl)-4-hydroxyiminomethylpyridinium bromide
78282-91-4

1-(2-bromomethylbenzyl)-4-hydroxyiminomethylpyridinium bromide

3-carbamoyl-2'-hydroxyiminomethyl-1,1'-(1,4-phenylenedimethylene)-bispyridinium dibromide

3-carbamoyl-2'-hydroxyiminomethyl-1,1'-(1,4-phenylenedimethylene)-bispyridinium dibromide

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 70℃; for 3.5h;98%
In N,N-dimethyl-formamide at 80℃; for 5h;56%
nicotinamide
98-92-0

nicotinamide

lamotrigine
84057-84-1

lamotrigine

C6H6N2O*C9H7Cl2N5
1151890-36-6

C6H6N2O*C9H7Cl2N5

Conditions
ConditionsYield
at 125℃; for 2.5h;98%
In methanol at 50℃; for 2h;
5-hydroxypentylamine
2508-29-4

5-hydroxypentylamine

nicotinamide
98-92-0

nicotinamide

N-(5-hydroxypentyl)nicotinamide
1613058-38-0

N-(5-hydroxypentyl)nicotinamide

Conditions
ConditionsYield
With niobium(V) oxide In neat (no solvent) at 160℃; Sealed tube; Inert atmosphere;98%
3-Aminomethylpyridine
3731-52-0

3-Aminomethylpyridine

nicotinamide
98-92-0

nicotinamide

N-(pyridin-3-ylmethyl)nicotinamide
25297-38-5

N-(pyridin-3-ylmethyl)nicotinamide

Conditions
ConditionsYield
With benzoic acid In para-xylene at 130℃; for 8h; Inert atmosphere; Schlenk technique;98%
1-Bromotetradecane
112-71-0

1-Bromotetradecane

nicotinamide
98-92-0

nicotinamide

3-carbamoyl-1-tetradecylpyridinium bromide
5442-84-2

3-carbamoyl-1-tetradecylpyridinium bromide

Conditions
ConditionsYield
In acetonitrile for 48h; Reflux;98%

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