114117-12-3

Upstream product

• 100-39-0 benzyl bromide 
• 65207-55-8 D-lactal 
• 51450-24-9 hexa-O-acetyl-D-lactal 
• 100-44-7 benzyl chloride 

Downstream Products

• 303966-47-4 hexa-O-benzyl-lactal-1,2α-epoxide 
• 911028-31-4 (3R,4R,5R)-3,6-bis(benzyloxy)-4-(2',3',4',6'-tetra-O-benzyl-β-D-galactopyranosyl)hexane-1,5-diol 
• 1103257-28-8 methyl 3,6,8,9,10,12-hexa-O-benzyl-2-deoxy-2-epi-2-C-nitromethyl-α-D-lactopyranoside 
• 1103257-27-7 methyl 3,6,8,9,10,12-hexa-O-benzyl-2-deoxy-2-C-nitromethyl-β-D-lactopyranoside 
• 211925-92-7 (E)-(2R,3R,4R)-1,4-Bis-benzyloxy-6-methoxy-3-((2S,3R,4S,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-hex-5-en-2-ol 
• 37699-01-7 3,4,6-tri-O-benzyl-2,5-anhydro-D-allose dimethylacetal 

Relevant academic research and scientific papers

Electrochemical Trifluoromethylation of Glycals

Carbohydrates play essential roles in various physiological and pathological processes. Trifluoromethylated compounds have wide applications in the field of medicinal chemistry. Herein, we report a practical and efficient trifluoromethylation of glycals b

1-Oxabicyclic β-lactams as new inhibitors of elongating MPT-a key enzyme responsible for assembly of cell-surface phosphoglycans of Leishmania parasite

New iminosugars (1-oxabicyclic β-lactam disaccharides) have been synthesized as inhibitors of elongating α-D-mannosyl phosphate transferase (eMPT), a key enzyme involved in the iterative biosynthesis of cell-surface phosphoglycans of the Leishmania parasi

Synthesis of the tetrasaccharide cap domain of the antigenic lipophosphoglycan of Leishmania donovani parasite

In this paper we report a new synthesis of the immunologically important tetrasaccharide terminal cap domain [Galp(1-4)-β-[Manp-(1-2)-α-Manp-(1-2)-α]-Manp] of lipophosphoglycan (LPG); the major cell surface GPI molecule and key virulence factor of the protozoan parasite Leishmania donovani. The synthetic approach provided a short convergent route for the LPG cap motif from lactose and mannose starting materials. The synthesis was then applied for the preparation of a radiolabelled cap epitope for macrophage receptor binding and immunological studies. (C) 2000 Elsevier Science Ltd.

APPLICATION OF THE TRICHLOROACETIMIDATE METHOD TO THE SYNTHESIS OF GLYCOPEPTIDES OF THE MUCIN TYPE CONTAINING A β-D-Galp-(1->3)-D-GalpNAc UNIT

Mucin-type O-glycopeptides containig the β-D-Galp-(1->3)-D-GalpNAc disaccharide core unit, which is also the T-antigenic determinant, were synthesized from D-galactose, 2-azido-2-deoxy-D-galactose, 2-azido-2-deoxylactose, and L-serine precursors by applying the trichloroacetimidate method.Thus, β-D-Galp-(1->3)-α-D-GalpNAc-(1->3)-Ser (1) and β-D-Galp-(1->4)-β-D-GlcpNAc-(1->6)-3)>-α-D-GalpNAc-(1->3)-Ser (2) were obtained.A protected precursor of 2 having free OH groups at C-4 and C-6 of the inner sugar unit is a valuable intermediate for the synthesis of further O-glycopeptides of this core-unit type.