1141365-47-0Relevant articles and documents
Formal synthesis of berkelic acid: A lesson in α-alkylation chemistry
McLeod, Michael C.,Wilson, Zoe E.,Brimble, Margaret A.
, p. 400 - 416 (2012/02/15)
The full details of our enantioselective formal synthesis of the biologically active natural product berkelic acid are described. The insertion of the C-18 methyl group proved challenging, with three different approaches investigated to install the correc
A diastereoselective formal synthesis of berkelic acid
Wenderski, Todd A.,Marsini, Maurice A.,Pettus, Thomas R. R.
, p. 118 - 121 (2011/04/15)
A formal synthesis of berkelic acid is reported. The strategy employs the combination of a chiral exocyclic enol ether and an achiral isochromanone to afford the chroman spiroketal core via a base-triggered generation and cycloaddition of an o-quinone met
Introduction of the (-)-berkelic acid side chain and assignment of the C-22 stereochemistry
Wu, Xiaoxing,Zhou, Jingye,Snider, Barry B.
supporting information; experimental part, p. 6245 - 6252 (2010/01/06)
(Chemical Equation Presented) A Kiyooka aldol condensation of an aldehyde with a trimethylsilyl ketene acetal and the oxazaborolidinone prepared from N-Ts-(S)-valine gives two of the four possible aldol adducts, which were oxidized and deprotected to comp