1182098-75-4

Upstream product

• 1141365-67-4 (3S,4S)-dihydro-4-[2-[(1,1-dimethylethyl)diphenylsilyloxy]ethyl]-3-methyl-2(3H)-furanone 
• 1260148-60-4 C₂₄H₃₂O₂Si 
• 1260148-61-5 methyl 2-(3,5-bis(benzyloxy)-2-formylphenyl)acetate 
• 1260148-62-6 C₁₇H₁₆O₅ 
• 1260148-63-7 C₁₇H₁₅IO₅ 
• 1260148-51-3 C₁₆H₁₃IO₄ 
• 1260148-68-2 C₄₀H₄₅IO₆Si 
• 1260148-65-9 C₄₀H₄₃IO₆Si 
• 1260148-55-7 C₄₅H₅₃IO₅Si 
• 4724-10-1 methyl 2-(3,5-dihydroxyphenyl)acetate 
• 4670-09-1 2-(3,5-dihydroxyphenyl)acetic acid 
• 693-25-4 n-pentylmagnesium bromide 
• 79762-35-9 methyl 2-(3,5-bis(benzyloxy)-2-formylphenyl)acetate 
• 1333325-49-7 (3S,4S)-4-(2-tert-butyldiphenylsilyloxyethyl)-2,3-dimethyltetrahydrofuran-2-ol 

Downstream Products

• 1141365-47-0 2-propenyl (2S,3S,3'aS,4S,5'R)-4-[2-[(1,1-dimethylethyl)diphenylsilyloxy]ethyl]-3',3'a,4,5,5',6'-hexahydro-3-methyl-5'-pentyl-8'-(2-propenyloxy)-spiro[furan-2(3H),2'-[2H]pyrano[2,3,4-de][1]benzopyran]-9'-carboxylate 

Relevant academic research and scientific papers

Formal synthesis of berkelic acid: A lesson in α-alkylation chemistry

The full details of our enantioselective formal synthesis of the biologically active natural product berkelic acid are described. The insertion of the C-18 methyl group proved challenging, with three different approaches investigated to install the correc

An Enantioselective formal synthesis of berkelic acid

An enantioselective formal synthesis of berkelic acid is described. The key step involves a late-stage silyl enol ether addition to a benzannulated oxonium ion with subsequent spiroketalization leading to construction ofthe tetracyclic core. Thermodynamic

A diastereoselective formal synthesis of berkelic acid

A formal synthesis of berkelic acid is reported. The strategy employs the combination of a chiral exocyclic enol ether and an achiral isochromanone to afford the chroman spiroketal core via a base-triggered generation and cycloaddition of an o-quinone met