114195-15-2

Upstream product

• 139148-39-3 methyl 3-oxo-3-(3,4,5-trimethoxyphenyl)propanoate 
• 18457-04-0 bis(trimethylsilyl) malonate 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 

Downstream Products

• 592529-07-2 2-pyrrolidin-2-yl-1-(3,4,5-trimethoxy-phenyl)-ethanone 
• 945772-27-0 3-methoxyphenyl 3-oxo-3-(3,4,5-trimethoxyphenyl)propanoate 
• 1644085-85-7 4,4,4-trifluoro-3-hydroxy-1-(3,4,5-trimethoxyphenyl)butan-1-one 
• 1604833-40-0 (R)-2-(2,2-dioxido-3,4-dihydrobenzo[e][1,2,3]oxathiazin-4-yl)-1-(3,4,5-trimethoxyphenyl)ethan-1-one 
• 592529-09-4 2-{1-[2-(3-Benzyloxy-4-methoxy-phenyl)-acetyl]-pyrrolidin-2-yl}-1-(3,4,5-trimethoxy-phenyl)-ethanone 
• 592528-81-9 6-(3-benzyloxy-4-methoxy-phenyl)-7-(3,4,5-trimethoxy-phenyl)-2,3,8,8a-tetrahydro-1H-indolizin-5-one 

Relevant academic research and scientific papers

SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS

The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerisation inhibitors.

Novel 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues as cytotoxic agents

A series of 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues were synthesized and evaluated for cytotoxic activity against eight human cancer cell lines. Compounds 18, 21, 28, 29, 30 and 31 showed cytotoxic activity with GI50 value