139148-39-3

Upstream product

• 38330-80-2 monomethyl monopotassium malonate 
• 118-41-2 Eudesmic acid 

Downstream Products

• 802916-53-6 C₁₆H₂₁NO₆ 
• 155004-78-7 methyl 3,4-methylenedioxy-6-(3',4',5'-trimethoxybenzoyl)phenylacetate 
• 1345834-45-8 methyl 3-methyl-5-oxo-2-(3,4,5-trimethoxybenzoyl)pentanoate 
• 592529-09-4 2-{1-[2-(3-Benzyloxy-4-methoxy-phenyl)-acetyl]-pyrrolidin-2-yl}-1-(3,4,5-trimethoxy-phenyl)-ethanone 
• 592528-81-9 6-(3-benzyloxy-4-methoxy-phenyl)-7-(3,4,5-trimethoxy-phenyl)-2,3,8,8a-tetrahydro-1H-indolizin-5-one 
• 592529-07-2 2-pyrrolidin-2-yl-1-(3,4,5-trimethoxy-phenyl)-ethanone 
• 21742-02-9 3-Amino-4-(3,4,5-trimethoxy-phenyl)furazan 
• 114195-15-2 3-oxo-3-(3,4,5-trimethoxyphenyl)propionic acid 

Relevant academic research and scientific papers

Expedient synthesis of 3-hydroxyisoquinolines and 2-hydroxy-1,4- naphthoquinones via one-pot aryne acyl-alkylation/condensation

A convenient method is disclosed for the synthesis of both 3-hydroxyisoquinolines and 2-hydroxy-1,4-naphthoquinones from β-ketoesters using a one-pot aryne acyl-alkylation/condensation procedure. When performed in conjunction with a one-step method for the synthesis of the β-ketoester substrates, this method provides a new route to these polyaromatic structures in only two steps from commercially available carboxylic acid starting materials. The utility of this approach is demonstrated in the synthesis of the atropisomeric P,N-ligand, QUINAP. The Royal Society of Chemistry 2009.

Discovery and structure-activity relationships of trisubstituted pyrimidines/pyridines as novel calcium-sensing receptor antagonists

The trisubstituted pyrimidine 1 was identified through high-throughput screening as a novel calcium-sensing receptor (CaSR) antagonist. Small molecule CaSR antagonists and/or negative allosteric modulators have the potential to act as an anabolic agent for the treatment of osteoporosis. The investigation of structure-activity relationships around 1 resulted in the identification of 18c and 18d, which showed efficacy at promoting PTH release in vivo and exhibited improved potency and solubility over the original lead 1.

TRISUBSTITUTED HETEROAROMATIC COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS

Trisubstituted heteroaromatic compounds having the structure Formula (I) are provided, wherein X is C or N; A and B are each independently CH or N, with the proviso that A and B cannot both be CH; R is Ar-L-; R is hydrogen or alkyl; or R and R can be joined together to form a 4- to 7-membered cycloheteroalkyl ring; R to R, Ar and L are as defined herein. A method for using these compounds to treat diseases associated with abnormal bone or mineral homeostasis is also provided.