114217-91-3

Upstream product

• 495-18-1 Benzohydroxamic acid 
• 58696-10-9 R,R-ketobenzamide 
• 114217-83-3 methyl 7,8-diacetoxy-3-benzoyl-2-oxa-3,5-diazabicyclo<2.2.2>octane-5-carboxylate 
• 94936-52-4 methyl 3-benzoyl-2-oxa-3,5-diazabicyclo<2.2.2>oct-7-ene-5-carboxylate 
• 33707-36-7 1-(methoxycarbonyl)-1,2-dihydropyridine 
• 108-24-7 acetic anhydride 

Relevant academic research and scientific papers

Syntheses of Diamino-dideoxylyxose Derivatives using Acylnitroso Dienophiles

N-Acylnitroso derivatives 6 which were prepared by in-situ oxidation of the corresponding hydroxamic acids 5 reacted instantaneously and in high yields with dihydropyridine 4.The Diels-Alder adducts 8 were formed regiospecifically with the acylnitroso dienophiles 6a-c, whereas the dienophiles 6d-f gave mixtures of both regioisomers 7 and 8.These and some other results were best explained by the FMO theory.The Diels-Alder adducts 7 and 8 gave the corresponding 'anti'-cis-glycols when reacted with OsO4/N-methylmorpholine N-oxide.Hydrogenolysis of the N-O bond folloved by peracetylation led to the expected aminolyxose derivatives 14 and 16.A similar sequence, using 4 and the hydroxamic-acid derivative 18 of (+)-D-mandelic acid led, with a poor assymmetric induction, to a mixture of the expected optically active aminolyxose compounds 19A/19B.

SYNTHESIS OF RACEMIC DIAMINO-DIDEOXY-LYXOPYRANOSE DERIVATIVES USING ACILNITROSO DIENOPHILES (1).

Acylnitroso derivatives, which are obtained by in situ oxidation of the corresponding hydroxamic acids with tetraalkylammonium iodate, react intantaneously in the presence of dihydropyridine 1 leading to the Diels-Alder adducts 4 and 5.These latter ones w