114299-63-7Relevant academic research and scientific papers
Metal-Free Three-Component Oxyalkynylation of Alkenes
Li, Yangshan,Lu, Ran,Sun, Shutao,Liu, Lei
, p. 6836 - 6839 (2018/10/25)
An unprecedented (NH4)2S2O8 mediated metal-free three-component alkene oxyalkynylation using H2O or alcohol as oxygenation agent is described. Mechanistic studies suggested that the reversed regiosele
Spirocyclic NK1 antagonists I: [4.5] and [5.5]-Spiroketals
Seward, Eileen M,Carlson, Emma,Harrison, Timothy,Haworth, Karen E.,Herbert, Richard,Kelleher, Fintan J.,Kurtz, Marc M.,Moseley, Jonathan,Owen, Simon N.,Owens, Andrew P.,Sadowski, Sharon J.,Swain, Christopher J.,Williams, Brian J.
, p. 2515 - 2518 (2007/10/03)
A series of novel spiroketal-based NK1 antagonists is described. The effect of modifications to the spiroether ring and aromatic substituents are discussed, leading to the identification of compounds with high affinity and excellent CNS penetration.
Palladium(II)-catalyzed formation of γ-butyrolactones from 4-trimethylsilyl-3-alkyn-1-ols: Synthetic and mechanistic aspects
Compain, Philippe,Gore, Jacques,Vatele, Jean-Michel
, p. 10405 - 10416 (2007/10/03)
γ-butyrolactones are obtained in good yields from 4-trimethylsilyl-3-alkyn-1-ols via Wacker-type oxidation reaction. A mechanism is proposed for this transformation: it involves two successive trans-hydroxypalladations followed by a [PdXSiMe3] syn-elimination and explains why the presence of the silyl group is essential in such a process.
The Ring Opening of Unsymmetrical Allylic, Benzylic, Propargylic, and Si-Substituted Epoxides by Titanium Acetylides: A Convenient Access to Certain 2-Substituted 3-Butyn-1-ols
Krause, Norbert,Seebach, Dieter
, p. 1315 - 1320 (2007/10/02)
Epoxides bearing aryl, alkenyl, alkynyl, and trimethylsilyl substituents react with titanium acetylides at the higher substituted carbon atom exclusively; the 2-substituted 3-butyn-1-ols thus formed are isolated in 33-79percent yield.The dependence of the yield on the solvent, the ratio of the reactands, and their structure is discussed and a reaction mechanism is proposed.
