1143-88-0

Upstream product

• 121732-95-4 N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)benzylideneamine 
• 31491-21-1 2-phenyl-1,1-bis(trimethylsilyloxy)ethene 
• 21731-22-6 2,3-diphenyl-β-alanine 

Relevant academic research and scientific papers

Organocatalytic Mannich-type reactions of trifluoroethyl thioesters

(Chemical Equation Presented) Direct organocatalytic Mannich-type reactions of thioesters provide for the expedient and diastereoselective synthesis of protected β-amino acids. A variety of thioesters were found to be reactive with different lmines under mild conditions to provide β-amino acids in good yields. This chemistry was extended to a diastereo- and enantioselective variant.

Asymmetric mannich synthesis of β-amino acids with two new stereogenic centers at the α and β positions

α-Branched β-amino acids 1 with erythro configuration can be made selectively and with high asymmetric induction by the reaction of O-pivaloyl-protected N-galactosylaldimines 2 with prochiral bissilyl) ketene acetals 3. The corresponding reaction with the prochiral lithium ester enolate 4 exclusively leads to the threo-configured β-amino acid derivatives.