21731-22-6Relevant academic research and scientific papers
Asymmetric mannich synthesis of β-amino acids with two new stereogenic centers at the α and β positions
Kunz,Burgard,Schanzenbach
, p. 386 - 387 (2007/10/03)
α-Branched β-amino acids 1 with erythro configuration can be made selectively and with high asymmetric induction by the reaction of O-pivaloyl-protected N-galactosylaldimines 2 with prochiral bissilyl) ketene acetals 3. The corresponding reaction with the prochiral lithium ester enolate 4 exclusively leads to the threo-configured β-amino acid derivatives.
