114342-75-5Relevant academic research and scientific papers
Synthesis and Some Properties of D-myo-Inositol 1,4,5-Tris(dihydrogen phosphate)
Ozaki, Shoichiro,Kondo, Yoshihisa,Shiotani, Naokazu,Ogasawara, Tomio,Watanabe, Yutaka
, p. 729 - 738 (2007/10/02)
Optically active myo-inositol 1,4,5-tris(dihydrogen phosphate) 1, which has now been recognized as a second messenger in a new intracellular signal transduction system, has been prepared starting from myo-inositol.The key step, phosphorylation of an adequately protected polyhydroxy derivative, was accomplished by three methods, among which a phosphoramidite method using a new phosphitylating agent, o-xylylene N,N-diethylphosphoramidite, gave the triphosphoric ester in quantitative yield.Optical resolution was effectively realized by derivatization into diastereoisomeric l-menthoxyacetic esters.NMR spectra and optical rotation are shown to depend on the pH of an aqueous solution of compound 1.
Synthesis and biological properties of 2-substituted myo-inositol 1,4,5-trisphosphate analogues directed toward affinity chromatography and photoaffinity labeling
Ozaki, Shoichiro,Watanabe, Yutaka,Ogasawara, Tomio,Hirata, Masato,Kanematsu, Takashi
, p. 189 - 206 (2007/10/02)
A series of myo-inositol 1,4,5-trisphosphate analogues with the 2-acyl substituents p-aminobenzoyl (7), p-azidobenzoyl (8), 4--2-hydroxyphenylazo>benzoyl (9), and cis,trans-4-aminocyclohexylcarbonyl (10) were synthesised and examine
A VERSATILE INTERMEDIATE, D-4,5-BIS(DIBENZYL PHOSPHORYL)-MYO-INOSITOL DERIVATIVE FOR SYNTHESIS OF INOSITOL PHOSPHATES. SYNTHESIS OF 1,2-CYCLIC-4,5-, 1,4,5-, AND 2,4,5-TRISPHOSPHATE
Watanabe, Yutaka,Ogasawara, Tomio,Nakahira, Hiroyuki,Matsuki, Tomoko,Ozaki, Shoichiro
, p. 5259 - 5262 (2007/10/02)
Practical synthesis of D-myo-inositol 1,2-cyclic-4,5-, 1,4,5-, and 2,4,5-trisphosphate was accomplished from the key synthetic intermediate, D-3,6-di-O-benzyl-4,5-di-O-(dibenzyl phosphoryl)-myo-inositol.
