1143516-05-5

Basic information

• Product Name: AEEA-AEEA
• Synonyms: AEEA-AEEA;AEEA-AEEA-AEEA;17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic acid;8-Amino-3,6-dioxaoctanoic acid dimer≥ 98% (HPLC);H-Adoa-Adoa-OH;H-AEEA-AEEA;H-AEEA-AEEA-OH
• CAS NO: 1143516-05-5
• Molecular Formula: C₁₂H₂₄N₂O₇
• Molecular Weight: 308.32816
• Mol File: 1143516-05-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 548.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.202±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)
• PKA: 3.39±0.10(Predicted)
• CAS DataBase Reference: AEEA-AEEA(CAS DataBase Reference)
• NIST Chemistry Reference: AEEA-AEEA(1143516-05-5)
• EPA Substance Registry System: AEEA-AEEA(1143516-05-5)

Safety Data

• Hazardous Substances Data: 1143516-05-5(Hazardous Substances Data)

Usage

Description

AEEA-AEEA, also known as 17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic Acid, is a white crystalline powder with unique chemical properties. It is a versatile compound that can be used for the preparation of glutamic acid-containing acylating reagents.

Uses

Used in Pharmaceutical Industry:
AEEA-AEEA is used as a precursor for the preparation of glutamic acid-containing acylating reagents for selective acylation of amino group(s) in peptides or proteins. This selective acylation is crucial for the development of novel drugs and therapeutic agents that target specific protein functions.
Used in Biochemistry Research:
AEEA-AEEA is used as a research tool in biochemistry to study the interactions between peptides, proteins, and other biomolecules. Its ability to selectively acylate amino groups allows researchers to investigate the structure, function, and regulation of proteins in various biological systems.
Used in Drug Development:
AEEA-AEEA is used in the development of new drugs and therapeutic agents that target specific proteins involved in various diseases. By selectively acylating amino groups, AEEA-AEEA can help in the design and synthesis of drugs with improved specificity, efficacy, and safety profiles.

Upstream product

• 1069067-08-8 2,2-dimethyl-4,13-dioxo-3,8,11,17,20-pentaoxa-5,14-diazadocosan-22-oic acid 

Relevant articles and documents

A universal and ready-to-use heterotrifunctional cross-linking reagent for facile synthetic access to sophisticated bioconjugates

We describe for the first time, the synthesis and some bioconjugation applications of an original heterotrifunctional cross-linking reagent (also named tripod) bearing three different bioorthogonal functional groups which are fully compatible amongst themselves. Contrary to the first generation tripod recently reported by us (Org. Biomol. Chem., 2008, 6, 3065), the use of an azido group instead of the nucleophile-sensitive active carbamate moiety enables us to reach the targeted chemical orthogonality without the use of temporary aminooxy- and thiol protecting groups. Thus, the preparation of sophisticated bioconjugates through the sequential derivatisation of the tripod by means of copper-mediated 1,3-dipolar cycloaddition, oxime ligation and aqueous compatible mild thiol-alkylation reactions, is significantly simpler and more convenient. The chemoselective bioconjugation protocols were optimised through the preparation of FRET cassettes based on cyanine and/or xanthene fluorescent dye pairs and subsequent anchoring to fragile biomolecules. The applicability of this universal cross-linking reagent was also illustrated by the preparation of biochips suitable for aflatoxin B1 detection through the SPIT-FRI method.