114358-14-4Relevant articles and documents
Solvent-free organocatalytic asymmetric conjugate addition of thiols to α,β-unsaturated aldehydes
Ishino, Takeru,Oriyama, Takeshi
, p. 550 - 551 (2007)
A highly enantioselective asymmetric conjugate addition of thiols to α,β-unsaturated aldehydes has been achieved catalyzed by newly designed organocatalyst without solvent. Copyright
CONFORMATIONALLY CONSTRAINED MACROCYCLIC COMPOUNDS
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Page/Page column 43, (2017/05/02)
Conformationally constrained macrocyclic compounds of formula (I), including substituents E with at least one ester moiety, G and Q, as defined in the description and the claims, and salts thereof, can be metabolized to compounds that have the property to
Process Development and Synthesis of Birinapant: Large Scale Preparation and Acid-Mediated Dimerization of the Key Indole Intermediate
Deng, Yijun,Xie, Qiuzhe,LaPorte, Matthew G.,Chasnoff, Anna T. A.,Mortensen, Mark A.,Patra, Debasis,Putrelo, Seth A.,Antonovich, Robert S.,Cao, Hong,Yan, Jun,Cooper, Arthur J.,Rippin, Susan R.,Alexander, Matthew D.,Kumar, Pavan Tirunahari,Hendi, Mukta S.,Lee, Yu-Hua,Haimowitz, Thomas,Condon, Stephen M.
, p. 242 - 252 (2016/03/04)
Birinapant/TL32711 (1) is a novel bivalent antagonist of the inhibitor of apoptosis (IAP) family of proteins which is currently in clinical development for the treatment of cancer and hepatitis B virus (HBV) infection. In this report, we present a detaile