114384-17-7Relevant academic research and scientific papers
Ruthenium(II) complexes of 4-nitroimidazoles: their characterization, solution chemistry, and radiosensitizing activity
Chan, Peter K. L.,Chan, Paul K. H.,Frost, David C.,James, Brian R.,Skov, Kirsten A.
, p. 117 - 122 (2007/10/02)
A series of ruthenium(II) complexes of formulation RuCl2(dmso)2Ln, where dmso=S-bonded dimethylsulfoxide, L is a 4-nitroimidazole derivative, and n=1 or 2, have been synthesized and characterized by spectroscopic methods, particularly 1H nmr and X-ray photoelectron spectroscopy.With L=4-nitroimidazole itself (4-NO2Im), RSU-1170, -3083 or -3100, n=2 and the six-coordinate complexes are considered to be cis,cis,cis-geometry.The N-methyl-4-nitroimidazole (NMe-4-NO2Im) ligand (n=1) chelates through the imidazole-N and the oxygen of NO2.The RSU-3159 ligand (n=1) binds through the sulfur and may be chelated.The complexes are of interest because of their radiosensitizer properties toward hypoxic tumour cells; the RuCl2(dmso)2(NMe-4-NO2Im) complex has a higher sensitizing enhancement ratio than the free imidazole ligand, and shows no cytoxicity in vitro, and these data are compared to those reported previously for RuCl2(dmso)2(4-NO2Im)2.Some aspects of the aqueous solution chemistry of the complexes (aquation via loss of chloride, pKa of coordinated water) are discussed in relation to their biological activities.
