105313-65-3

Basic information

• Product Name: ruthenium chloride-DMSO(2)-4-nitroimidazole(2)
• Synonyms: ruthenium chloride-DMSO(2)-4-nitroimidazole(2)
• CAS NO: 105313-65-3
• Molecular Formula: C₁₀H₁₈Cl₂N₆O₆RuS₂
• Molecular Weight: 552.37664
• Mol File: 105313-65-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 582.9°Cat760mmHg
• Flash Point: 306.3°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 1.42E-13mmHg at 25°C
• CAS DataBase Reference: ruthenium chloride-DMSO(2)-4-nitroimidazole(2)(CAS DataBase Reference)
• NIST Chemistry Reference: ruthenium chloride-DMSO(2)-4-nitroimidazole(2)(105313-65-3)
• EPA Substance Registry System: ruthenium chloride-DMSO(2)-4-nitroimidazole(2)(105313-65-3)

Safety Data

• Hazardous Substances Data: 105313-65-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H13N3O4S2.C3H3N3O2.2ClH.Ru/c1-15(13)4-6-8-3-7(10(11)12)9(6)5-16(2)14;7-6(8)3-1-4-2-5-3;;;/h3,6,8H,4-5H2,1-2H3;1-2H,(H,4,5);2*1H;/q;;;;+2/p-2/t6?,15?,16-;;;;/m0..../s1

Upstream product

• 194497-67-1 cis-[RuCl₂(DMSO)4] 
• 3034-38-6 1H-4⁽⁵⁾-nitroimidazole 

Downstream Products

• 114384-17-7 {ruthenium(II)(Cl)(H₂O)(dimethylsulfoxid)2(4-nitroimidazole)2}⁽¹⁺⁾ 
• 16887-00-6 chloride 
• 114384-18-8 ruthenium(II)(Cl)(OH)(dimethylsulfoxid)2(4-nitroimidazole)2 

Relevant articles and documents

Ruthenium(II) complexes of 4-nitroimidazoles: their characterization, solution chemistry, and radiosensitizing activity

A series of ruthenium(II) complexes of formulation RuCl2(dmso)2Ln, where dmso=S-bonded dimethylsulfoxide, L is a 4-nitroimidazole derivative, and n=1 or 2, have been synthesized and characterized by spectroscopic methods, particularly 1H nmr and X-ray photoelectron spectroscopy.With L=4-nitroimidazole itself (4-NO2Im), RSU-1170, -3083 or -3100, n=2 and the six-coordinate complexes are considered to be cis,cis,cis-geometry.The N-methyl-4-nitroimidazole (NMe-4-NO2Im) ligand (n=1) chelates through the imidazole-N and the oxygen of NO2.The RSU-3159 ligand (n=1) binds through the sulfur and may be chelated.The complexes are of interest because of their radiosensitizer properties toward hypoxic tumour cells; the RuCl2(dmso)2(NMe-4-NO2Im) complex has a higher sensitizing enhancement ratio than the free imidazole ligand, and shows no cytoxicity in vitro, and these data are compared to those reported previously for RuCl2(dmso)2(4-NO2Im)2.Some aspects of the aqueous solution chemistry of the complexes (aquation via loss of chloride, pKa of coordinated water) are discussed in relation to their biological activities.