1144-81-6

Basic information

• Product Name: p-(o-Nitrophenylthio)aniline
• Synonyms: p-(o-Nitrophenylthio)aniline
• CAS NO: 1144-81-6
• Molecular Formula: C₁₂H₁₀N₂O₂S
• Molecular Weight: 0
• Mol File: 1144-81-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: p-(o-Nitrophenylthio)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: p-(o-Nitrophenylthio)aniline(1144-81-6)
• EPA Substance Registry System: p-(o-Nitrophenylthio)aniline(1144-81-6)

Safety Data

• Hazardous Substances Data: 1144-81-6(Hazardous Substances Data)

Upstream product

• 4837-33-6 o-nitrobenzenesulfenanilide 
• 62-53-3 aniline 
• 4837-32-5 S-(2-nitrophenyl)-N-(p-tolyl)thiohydroxylamine 
• 88-73-3 2-Chloronitrobenzene 
• 1193-02-8 4-aminotiophenol 
• 100-00-5 4-chlorobenzonitrile 
• 95-51-2 o-chloroaniline 
• 125771-28-0 2-nitro-benzenesulfenic acid-(2-chloro-anilide) 
• 57948-40-0 2-nitro-benzenesulfenic acid o-toluidide 

Downstream Products

• 6259-01-4 2-[(4-aminophenyl)thio]benzenamine 
• 30213-97-9 4-acetylamino-2'-nitrodiphenyl sulfide 
• 77915-83-4 2-methyl-3-o'-nitrodiphenylsulphidoquinazol-4-one 
• 78428-28-1 2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-N-[4-(2-nitro-phenylsulfanyl)-phenyl]-acetamide 
• 78428-30-5 2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-N-[4-(2-nitro-phenylsulfanyl)-phenyl]-acetamide 
• 78428-32-7 2-{[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-amino}-N-[4-(2-nitro-phenylsulfanyl)-phenyl]-acetamide 
• 78428-36-1 2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-N-[4-(2-nitro-phenylsulfanyl)-phenyl]-propionamide 
• 78428-37-2 2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-N-[4-(2-nitro-phenylsulfanyl)-phenyl]-propionamide 
• 78428-43-0 2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-3-methyl-N-[4-(2-nitro-phenylsulfanyl)-phenyl]-butyramide 
• 78428-62-3 2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-N-[4-(2-nitro-benzenesulfonyl)-phenyl]-acetamide 
• 78428-39-4 2-{[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-amino}-N-[4-(2-nitro-phenylsulfanyl)-phenyl]-propionamide 
• 78428-64-5 2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-N-[4-(2-nitro-benzenesulfonyl)-phenyl]-acetamide 
• 78428-26-9 2-{[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-amino}-N-[4-(2-nitro-phenylsulfanyl)-phenyl]-acetamide 
• 78428-70-3 2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-N-[4-(2-nitro-benzenesulfonyl)-phenyl]-propionamide 

Relevant articles and documents

New potent inhibitors of trypanothione reductase from Trypanosoma cruzi in the 2-aminodiphenylsulfide series

From a screening assay, 2-aminodiphenylsulfides were selected as leads for trypanothione reductase (TR) inhibition and studied by molecular modelling in the catalytic site of the enzyme. A series of analogues, monomers or bis-derivatives, were synthesized to improve binding energy and therefore inhibiting potency. These compounds appeared to be mixed competitive TR inhibitors and their inhibition profile could be explained when their aggregation in solution was taken into consideration. A bis-aminodiphenylsulfide with an IC50 of 0.55 μM was revealed to be the best TR inhibitor described so far.