1144016-35-2Relevant academic research and scientific papers
Retention of stereochemistry in the microwave assisted synthesis of 1H-tetrazole bioisosteric moiety from chiral phenyl-acetic acid derivatives
Tomassetti, Mara,Fanì, Michela,Bianchini, Gianluca,Giuli, Sandra,Aramini, Andrea,Colagioia, Sandro,Nano, Giuseppe,Lillini, Samuele
, p. 6247 - 6250 (2013/10/22)
Chiral substituted phenylethyl-1H-tetrazoles were built-up from the corresponding carboxylic acid derivatives by a useful three-step synthesis. The procedure, that preserves the chiral center from racemization, was successfully applied to a selection of several hit compounds by conversion of the carboxylic acid moiety to the nitrile derivatives and subsequent reaction with trimethylstannyl azide, under microwave conditions. A useful application to the corresponding tetrazole analogue has been found also in the conversion of the aminoacidic moiety like (R)-N-Cbz-phenylglycine showing a wide potential synthetic application.
