1144111-27-2Relevant articles and documents
Stereoselective synthesis of highly substituted α-silylamines from silylmethyl azides under Ru catalysis
Jeong, Wook,Kim, Jungjoon,Park, Jaiwook,Rhee, Young Ho
, p. 7577 - 7581 (2014)
A synthetic strategy towards highly substituted α-silyl homoallylic amines was discovered. The key event is the unique synthesis of N-unsubstituted α-silylimines from azide precursors under mild conditions. Of particular note is the unprecedented access to α-silylamines possessing multiple stereocenters and functional groups with high diastereo-and enantioselectivity. The synthetic utility of the method was demonstrated by the use of the silyl moiety as the key element that enables late-stage modification for the iminium ion mediated oxidative cyclization.
