1144161-10-3Relevant academic research and scientific papers
Pyrido[2,3-e]-1,2,4-triazolo[4,3-α]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies
Colotta, Vittoria,Lenzi, Ombretta,Catarzi, Daniela,Varano, Flavia,Filacchioni, Guido,Martini, Claudia,Trincavelli, Letizia,Ciampi, Osele,Pugliese, Anna Maria,Traini, Chiara,Pedata, Felicita,Morizzo, Erika,Moro, Stefano
experimental part, p. 2407 - 2419 (2010/04/30)
The paper describes a new class of human (h) A3 adenosine receptor antagonists, the 2-arylpyrido[2,3-e]- l,2,4-triazolo[4,3-α] pyrazin-1-one derivatives (PTP), either 4-oxo (1-6, series A) or 4-amino-substituted (7-20, series B). In both series
