37522-19-3

Basic information

• Product Name: Ethylchloro[(4-fluorophenyl)hydrazono]acetate
• Synonyms: Ethylchloro[(4-fluorophenyl)hydrazono]acetate
• CAS NO: 37522-19-3
• Molecular Formula: C₁₀H₁₀ClFN₂O₂
• Molecular Weight: 244.6500032
• Mol File: 37522-19-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethylchloro[(4-fluorophenyl)hydrazono]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethylchloro[(4-fluorophenyl)hydrazono]acetate(37522-19-3)
• EPA Substance Registry System: Ethylchloro[(4-fluorophenyl)hydrazono]acetate(37522-19-3)

Safety Data

• Hazardous Substances Data: 37522-19-3(Hazardous Substances Data)

Usage

General Description

Ethylchloro[(4-fluorophenyl)hydrazono]acetate is an organic compound with the chemical formula C10H11ClFNO2. It is a chlorinated ester derivative of acetate and contains a hydrazone functional group, which is a molecule containing a carbon-nitrogen double bond with adjacent substituents. Ethylchloro[(4-fluorophenyl)hydrazono]acetate is used in organic synthesis and pharmaceutical research as a building block in the production of various hydrazone derivatives. It can react with a variety of reagents to yield products with diverse pharmacological and chemical properties. Additionally, it is important to handle this compound with care due to its potential hazardous properties.

Upstream product

• 371-40-4 4-fluoroaniline 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 96734-84-8 ethyl 4-acetyl-1-(4-fluorophenyl)-5-methyl-1H-pyrazole-3-carboxylate 
• 115342-25-1 ethyl 1–(4-fluorophenyl)-1H-pyrazole-3-carboxylate 
• 96722-82-6 1-(4-Fluoro-phenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxylic acid diethyl ester 
• 129006-95-7 C₁₀H₁₂FN₃O₂ 
• 781663-68-1 ethyl 1-(4-fluorophenyl)-5-phenyl-1H-pyrazole-3-carboxylate 
• 1447583-79-0 ethyl 1-(4-fluorophenyl)-4-(10H-phenothiazine-2-carbonyl)-1H-pyrazole-3-carboxylate 
• 1427534-70-0 3-[3-(3,4-dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]-2-(4-fluorophenyl)-2,3,5,6-tetrahydro-8H-1,2,4-triazolo[3,4-c][1,4]oxazin-8-one 

Relevant articles and documents

Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists

Chemokine receptor 2 (CXCR2) is the receptor of glutamic acid–leucine–arginine sequence-contained chemokines CXCs (ELR+ CXCs). In recent years, CXCR2-target treatment strategy has come a long way in cancer therapy. CXCR2 antagonists could block

Design, synthesis and structure-activity relationships of novel 4-phenoxyquinoline derivatives containing 1,2,4-triazolone moiety as c-Met kinase inhibitors

A series of novel 4-phenoxyquinoline derivatives containing 1,2,4-triazolone moiety were synthesized and evaluated for their in?vitro cytotoxic activity against four cancer cell lines (HT-29, H460, A549 and MKN-45). Most of the compounds exhibited moderate-to-significant cytotoxicity. Compounds 33, 37, 39, 44, 46, 47, 53, 55, 61, 64 and 66 were further examined for their inhibitory activity against c-Met kinase. The most promising compound 47 (with c-Met IC50value of 1.57?nM) showed remarkable cytotoxicity against HT-29, H460, A549 and MKN-45?cell lines with IC50values of 0.08?μM, 0.14?μM, 0.11?μM and 0.031?μM, respectively, and thus it was 1.1- to 2.3- fold more potent than foretinib. Their preliminary structure-activity relationships (SARs) studies indicate that electron-withdrawing groups on the terminal phenyl rings are beneficial for improving the antitumor activity.

A new method for the synthesis of 1-aryl-1,2,4-triazole derivatives

A new and convenient one-step recyclization method for the synthesis of ethyl 1-aryl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-3-carboxylates is reported. Various ethyl chloro(2-arylhydrazinylidene)ethanoates react with thiazolidine-2,4-dione in the presence of potassium hydroxide to produce the 1-aryl-1,2,4-triazole derivatives in moderate to good yields. The procedure is economical, environmentally friendly and simple to perform. Georg Thieme Verlag Stuttgart - New York.