114417-19-5

Basic information

• Product Name: 4(1H)-Quinolinone, 7-chloro-1-(2,4-dichlorobenzoyl)-2,3-dihydro-
• CAS NO: 114417-19-5
• Molecular Formula: C16H10Cl3NO2
• Molecular Weight: 354.62
• Mol File: 114417-19-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4(1H)-Quinolinone, 7-chloro-1-(2,4-dichlorobenzoyl)-2,3-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Quinolinone, 7-chloro-1-(2,4-dichlorobenzoyl)-2,3-dihydro-(114417-19-5)
• EPA Substance Registry System: 4(1H)-Quinolinone, 7-chloro-1-(2,4-dichlorobenzoyl)-2,3-dihydro-(114417-19-5)

Safety Data

• Hazardous Substances Data: 114417-19-5(Hazardous Substances Data)

Upstream product

• 21617-15-2 7-chloro-1,2,3,4-tetrahydroquinolin-4-one 
• 89-75-8 2,4-dichlorobenzoyl chloride 

Downstream Products

• 114417-27-5 7-chloro-1-(2,4-dichlorobenzoyl)-2,3-dihydro-4(1H)-quinolinone-4-oxime 

Relevant articles and documents

Synthesis and diuretic activity of 2,3-dihydro-4(1H)-quinolinone 4-oxime-O-sulfonic acid derivatives

The diuretic activity of 6-chloro-2,3-dihydro-1-propionyl-4(1H)-quinolinone 4-oxime 1 (M12285) was previously shown to derive from a 6-chloro-2,3-dihydro-1-propionyl-4(1H)-quinolinone 4-oxime-O-sulfonic acid salt as a rat metabolite. Thus, in the present study, the potassium salt 2 (M17000) was synthesized to unambiguously establish the structure as well as the stereochemistry of the oxime. The structural features of compounds 1 and 2 were compared with those of conventional diuretics by electrostatic potential maps. Using compound 2 as a lead compound, various quinolinone oxime sulfonic acid derivatives were synthesized and the diuretic activity for elucidation of the structure-activity relationships examined. Among the compounds synthesized, 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(1H)-quinolinone 4-oxime-O-sulfonic acid potassium salt 3 (M17055) showed a particularly high activity. Elsevier, Paris.

1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives

The present invention relates to novel 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives, processes for producing said derivatives, intermediate compounds to produce said derivatives, processes to produce said intermediate compounds, and compositio