114418-44-9

Upstream product

• 100-52-7 benzaldehyde 
• 6004-44-0 prop-1-en-1-one 
• 780-25-6 N-benzylidene benzylamine 
• 16528-55-5 stannous 2-methyl-2-propanethiolate 
• 100-46-9 benzylamine 
• 61540-13-4 tert-butyl thiopropionate 

Downstream Products

• 4391-81-5 (3S,4R)-1-Benzyl-3-methyl-4-phenyl-azetidin-2-one 
• 114418-46-1 1-Benzyl-3-methyl-4-phenyl-2-azetidinon 

Relevant academic research and scientific papers

Highly enantioselective and diastereoselective synthesis of β-amino acid esters and β-lactams from achiral esters and imines

The reaction of S-tert-butyl thiopropionate with a number of N-benzyl or N-allyl aldimines (4) as promoted by the chiral diazaborolidine 1 and triethylamine afforded the β-amino acid esters 5 with high diastereoselectivity and enantioselectivity, providin

A NOVEL METHOD FOR THE STEREOSELECTIVE SYNTHESIS OF Β-AMINOACID DERIVATIVES VIA TIN(II) CARBOXYLIC THIOESTER ENOLATES

Tin(II) carboxylic thioester enolates, formed in situ from stannous 2-methyl-2-propanethiolate and ketenes, react with imines in the presence of stannous triflate to give the corresponding β-aminocarboxylic thioesters in an anti-selective manner.This method is successfully applied to a diastereoselective synthesis of a carbapenem antibiotic PS-5 intermediate.