114442-69-2Relevant academic research and scientific papers
TYLOSIN A ANALOGS AND DERIVATIVES
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Paragraph 0395, (2015/10/05)
The present invention pertains to derivatives of tylosin A. In particular, the present invention pertains to compounds having a structure of Formula (I). The present invention also pertains to compositions comprising derivatives of tylosin A and methods o
Application of dibutyltin oxide method to regioselective acylation and alkylation of tylosin at C-4''.
Kiyoshima,Sakamoto,Ishikura,Fukagawa,Yoshioka,Naganawa,Sawa,Takeuchi
, p. 861 - 865 (2007/10/02)
4''-O-Acyl-, 4''-O-alkyl- and 4''-deoxy-tylosin derivatives were synthesized using 2'-O-acetyl-3'',4''-O-(dibutyl-stannio)tylosin as a synthetic intermediate. The in vitro biological evaluation showed that the new derivatives were active against macrolide-resistant clinical isolates of bacteria and mycoplasmas, and that they were resistant to hepatic esterase.
