114445-80-6

Upstream product

• 56068-50-9 2,2-dimethylhex-5-en-1-ol 
• 18303-04-3 N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide 
• 84173-95-5 2,2-dimethyl-5-hexenenitrile 
• 53545-96-3 6-bromo-2,2-dimethylhexanenitrile 
• 98-59-9 p-toluenesulfonyl chloride 
• 141511-50-4 2,2-dimethyl-1-amino-5-hexene 

Downstream Products

• 691899-70-4 N-(2,2-dimethyl-hex-5-enyl)-N-ethynyl-4-methyl-benzenesulfonamide 
• 1196712-37-4 C₁₅H₂₂FNO₂S 
• 1196712-36-3 C₁₅H₂₂FNO₂S 
• 1404479-56-6 3,3,6-trimethyl-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydropyridine 

Relevant academic research and scientific papers

Copper-Catalyzed Carbonylative Synthesis of β-Homoprolines from N-Fluoro-sulfonamides

A new methodology for the carbonylative transformation of N-fluoro-sulfonamides into N-sulfonyl-β-homoproline esters has been described. In the presence of a catalytic amount of Cu(OTf)2, a range of β-homoproline derivatives were prepared in moderate to good yield. The reaction proceeds via the intramolecular cyclization and intermolecular carbonylation of a free carbon radical. Notably, this procedure offers the possibility to build potential functionalized bioactive molecules.

Sulfonamide-Directed Chemo- and Site-Selective Oxidative Halogenation/Amination Using Halogenating Reagents Generated in Situ from Cyclic Diacyl Peroxides

The combination of cyclic diacyl peroxides with commercially available halide salts as a unique halogenating system is utilized in Hofmann-L?ffler-Freytag-type reaction. This strategy allows for the formation of N-chloroamides, δ-brominated products, and

Rhodium(iii)-catalyzed allylic C-H bond amination. Synthesis of cyclic amines from ω-unsaturated N-sulfonylamines

For the first time, intramolecular allylic amination was conducted using rhodium(iii) according to an "inner-sphere" type mechanism with amines activated by only one electron-withdrawing group. The activation of C(sp 3)-H bonds was chemoselective and allows the access to a variety of substituted cyclic amines such as pyrrolidines and piperidines.

Radical cascade cyclizations and platinum(II)-catalyzed cycloisomerizations of ynamides

Ynamides are tested as new partners in radical and organometallic transformations. A radical cascade involving a 5-exo-dig cyclization followed by a 6-endo-trig radical trapping transforms ynamides into hetero-polycyclic compounds such as isoindoles, isoindolinones and pyrido-isoindolones. Various ene-tosylynamides react with platinum(II) chloride and lead to bicyclic nitrogenated heterocycles. This unprecedented and easily operated process can be coupled with a hydrolysis of the intermediate cyclic tosylenamides in a one-pot transformation, which provides cyclobutanones.

Platinum dichloride-catalyzed cycloisomerization of ene-ynamides

Various ene-tosylynamides react with platinum(II) chloride and lead to bicyclic nitrogenated heterocycles. This unprecedented and easily operated process can be coupled with a hydrolysis of the intermediate cyclic tosylenamides in a one-pot transformation